Lung Transplantation Questions & Answers

Updated: Aug 19, 2019
  • Author: Bryan A Whitson, MD, PhD; Chief Editor: Mary C Mancini, MD, PhD, MMM  more...
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Questions & Answers

Overview

How common are lung transplantations?

What is the cost effectiveness of lung transplantation?

What is living donor lung transplantation?

What is the evolution of lung transplantation procedures?

What are the indications for lung transplantation?

What are the ISHLT guidelines on the timing of referral and listing of candidates for lung transplantation?

Which factors determine the appropriate timing for referral to a lung transplant program?

What is the BODE index to assess the need for lung transplantation in patients with COPD?

What are the ISHLT criteria for referral and listing for lung transplantation in patients with COPD?

What are the ISHLT criteria for referral and listing for lung transplantation in patients with interstitial lung diseases?

What are the ISHLT criteria for referral and listing for lung transplantation in patients with cystic fibrosis and bronchiectasis?

What are the ISHLT criteria for referral and listing for lung transplantation in patients with pulmonary arterial hypertension?

What are the ISHLT absolute contraindications for lung transplantation?

Which extrapulmonary organ dysfunctions are absolute contraindications for lung transplantation?

What are the relative contraindications for lung transplantation?

Why is age a relative contraindication for lung transplantation?

Is atherosclerotic disease a contraindication for lung transplantation?

Which infections are relative contraindications for lung transplantation?

Why is ventilator dependence a relative contraindication for lung transplantation?

Which psychosocial issues are relative contraindications for lung transplantation?

Why are corticosteroids a relative contraindication for lung transplantation?

What are the contraindications for lung transplantation in patients with cystic fibrosis?

When is body weight a relative contraindication for lung transplantation?

Which comorbidities are relative contraindications for lung transplantation?

What are the reported outcomes following lung transplantation?

Workup

What is the role of lab tests in the pretransplant workup for lung transplantation?

What is included in the pretransplant workup for lung transplantation?

Treatment

Which transplant center features are associated with better lung transplantation outcomes?

What are the donor selection criteria for lung transplantation?

What is the waiting time for lung transplantation recipients?

When is heart-lung transplantation indicated?

When is double-lung transplantation indicated?

When is single-lung transplantation indicated?

Which factors affect the selection of lung transplantation procedure?

What is included in the preoperative evaluation of lung transplantation donors?

How are donor lungs managed prior to transplantation?

What are the criteria for brain death in a lung donor?

What is the difference in outcome between donation-after-cardiac death lung recipients and donation-after-brain-death lung recipients?

How are donor lungs preserved prior to transplantation?

How are patients monitored during lung transplantation?

How are single-lung transplantations performed?

How are donor lungs harvested for transplantation?

How are double-lung transplantations performed?

How are heart-lung transplantations performed?

Why is the postoperative period crucial in determining lung transplantation success?

What is included in postoperative respiratory management following lung transplantation?

What are the postoperative hemodynamics following lung transplantation?

What are the possible postoperative GI complications following lung transplantation?

What causes postoperative renal complications following lung transplantation?

What is included in postoperative fluid management following lung transplantation?

What is the role of antimicrobial therapy following lung transplantation?

How is nutrition maintained following lung transplantation?

What are the possible surgical complications from lung transplantation?

How are patients monitored in the immediate postoperative period following lung transplantation?

How are patients monitored in the early postoperative period following lung transplantation?

How are patients monitored in the late postoperative period following lung transplantation?

What is the role of immunosuppression in lung transplantation protocols?

What is the role of tacrolimus in lung transplantation?

What is the role of mycophenolate mofetil (MMF) in lung transplantation?

What is the role of cyclosporine in lung transplantation?

What is the role of azathioprine in lung transplantation?

What is the role of rapamycin in lung transplantation?

What is the role of corticosteroids in lung transplantation?

What is the role of antilymphocyte antibody preparations in lung transplantation?

What is the role of induction therapy in lung transplantation?

What is included in immunotherapy maintenance following lung transplantation?

What is reimplantation response following lung transplantation?

What is graft dysfunction following lung transplantation?

What are the ISHLT definition and diagnostic criteria for pulmonary antibody-mediated rejection (AMR)?

What is hyperacute AMR rejection following lung transplantation?

What causes hyperacute rejection of a lung transplant?

What is acute AMR rejection following lung transplantation?

How is rejection categorized following lung transplantation?

What causes acute rejection of a lung transplant and how is it managed?

What causes bronchiolitis obliterans syndrome (chronic rejection) following lung transplantation?

How is bronchiolitis obliterans syndrome (chronic rejection) following lung transplantation prevented and treated?

What are the possible airway complications of lung transplantation?

What are the possible vascular complications of lung transplantation?

What are the possible renal complications of lung transplantation?

Which infections may complicate a lung transplantation?

How are posttransplantation lymphoproliferative disorders (PTLDs) diagnosed and treated following lung transplantation?

What is the increased risk for cancer following lung transplantation?

Guidelines

Which organization has released guidelines on the timing of referral and listing for lung transplantation?

What are the ISHLT guidelines on selection of lung transplantation candidates with COPD?

What are the ISHLT guidelines on selection of lung transplantation candidates with interstitial lung disease?

What are the ISHLT guidelines on selection of lung transplantation candidates with cystic fibrosis?

What are the ISHLT guidelines on selection of lung transplantation candidates with pulmonary vascular diseases?

What are the ISHLT guidelines on selection of lung transplantation candidates with COPD?

What are the ISHLT guidelines on antibody-mediated rejection (AMR) of lung transplantation?