Posttransplant Lymphoproliferative Disease (PTLD) Differential Diagnoses

Updated: Aug 01, 2023
  • Author: Phillip M Garfin, MD, PhD; Chief Editor: Ron Shapiro, MD  more...
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Diagnostic Considerations

Posttransplant lymphoproliferative disease (PTLD) can present in a wide variety of ways. The differential diagnosis should include any condition that would be on the differential diagnosis appropriate for those particular symptoms in any patient. Patients who are immunosuppressed, in addition to being at risk for lymphoproliferative disease or opportunistic infections, are also at risk for the same conditions as patients who are immunocompetent. For example, if a patient who is immunosuppressed presents with fever, pharyngitis, and cervical lymphadenopathy, the differential diagnosis might include streptococcal infection and infectious mononucleosis, as well as PTLD.