Posttransplant Lymphoproliferative Disease Questions & Answers

Updated: Aug 09, 2018
  • Author: Phillip M Garfin, MD, PhD; Chief Editor: Ron Shapiro, MD  more...
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Questions & Answers

Overview

What is posttransplant lymphoproliferative disease (PTLD)?

How is posttransplant lymphoproliferative disease (PTLD) diagnosed?

How is posttransplant lymphoproliferative disease (PTLD) treated?

What are the histopathologic subtypes of posttransplant lymphoproliferative disease (PTLD)?

What is the pathophysiology of posttransplant lymphoproliferative disease (PTLD)?

What is the prevalence of posttransplant lymphoproliferative disease (PTLD)?

What is the prevalence of posttransplant lymphoproliferative disease (PTLD) following kidney transplantation?

What is the prevalence of posttransplant lymphoproliferative disease (PTLD) following heart transplantation?

What is the prevalence of posttransplant lymphoproliferative disease (PTLD) following liver transplantation?

What is the prevalence of posttransplant lymphoproliferative disease (PTLD) following lung transplantation?

What is the prevalence of posttransplant lymphoproliferative disease (PTLD) following hematopoietic stem cell transplantation (HSCT)?

What is the prognosis of posttransplant lymphoproliferative disease (PTLD)?

What are the prognostic indicators of posttransplant lymphoproliferative disease (PTLD)?

Presentation

What are the signs and symptoms of posttransplant lymphoproliferative disease (PTLD)?

What are most common sites of involvement in posttransplant lymphoproliferative disease (PTLD)?

DDX

Which conditions should be included in the differential diagnoses of posttransplant lymphoproliferative disease (PTLD)?

Workup

What is the role of lab testing in the workup of posttransplant lymphoproliferative disease (PTLD)?

How is a diagnosis of posttransplant lymphoproliferative disease (PTLD) confirmed?

What is the role of imaging studies in the workup of posttransplant lymphoproliferative disease (PTLD)?

What is the role of biopsy in the workup of posttransplant lymphoproliferative disease (PTLD)?

What is the role of lumbar puncture in the workup of posttransplant lymphoproliferative disease (PTLD)?

What are the categories for pathological diagnosis of posttransplant lymphoproliferative disease (PTLD)?

Treatment

What is the role of antiviral therapy in the treatment of posttransplant lymphoproliferative disease (PTLD)?

What is the role of antibody therapy in the treatment of posttransplant lymphoproliferative disease (PTLD)?

How is posttransplant lymphoproliferative disease (PTLD) treated?

What is the role of interferon alfa in the treatment of posttransplant lymphoproliferative disease (PTLD)?

What is the role of IV gamma globulin (IVIG) in the treatment of posttransplant lymphoproliferative disease (PTLD)?

What is the role of rituximab in the treatment of posttransplant lymphoproliferative disease (PTLD)?

What is the role of chemotherapy in the treatment of posttransplant lymphoproliferative disease (PTLD)?

How is CNS involvement in posttransplant lymphoproliferative disease (PTLD) treated?

How is the risk for posttransplant lymphoproliferative disease (PTLD) minimized?

What is the role of surgery in the treatment of posttransplant lymphoproliferative disease (PTLD)?

Guidelines

Which organizations have published treatment guidelines for posttransplant lymphoproliferative disease (PTLD)?

What are the NCCN diagnostic guidelines for posttransplant lymphoproliferative disease (PTLD)?

What are the AST diagnostic guidelines for posttransplant lymphoproliferative disease (PTLD)?

What are the NCCN treatment guidelines for posttransplant lymphoproliferative disease (PTLD)?

What are the AST treatment guidelines for posttransplant lymphoproliferative disease (PTLD)?

Medications

What is the role of medications in the treatment of posttransplant lymphoproliferative disease (PTLD)?

Which medications in the drug class Antineoplastic Agents are used in the treatment of Posttransplant Lymphoproliferative Disease?

Which medications in the drug class Immunomodulator Agents are used in the treatment of Posttransplant Lymphoproliferative Disease?

Which medications in the drug class Antiviral Agents are used in the treatment of Posttransplant Lymphoproliferative Disease?

Which medications in the drug class Immunosuppressive Agents are used in the treatment of Posttransplant Lymphoproliferative Disease?

Follow-up

What is included in the long-term monitoring of posttransplant lymphoproliferative disease (PTLD)?