Penile Cancer Medication

Updated: Jan 10, 2018
  • Author: Stanley A Brosman, MD; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and prevent complications. Topical 5-fluorouracil can be used for penile intraepithelial neoplasia. Chemotherapy regimens are used to treat patients with metastases beyond the pelvic and inguinal lymph nodes. 

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Antineoplastics

Class Summary

These agents inhibit cell growth and proliferation.

Cisplatin

Platinum coordination compound that inhibits DNA synthesis; cross-links and denatures strands of DNA; disrupts DNA function by covalently binding to DNA bases; can also produce DNA intrastrand cross-linking and breakage

Bleomycin

Glycopeptide antibiotic; inhibits DNA, RNA, protein synthesis in G2, M phases.

Methotrexate (Otrexup, Rasuvo, Rheumatrex)

Inhibits dihydrofolic acid reductase; inhibits purine and thymidylic acid synthesis, which in turn interferes with DNA synthesis, repair, and cellular replication; cell cycle specific for S phase of cycle

 

Ifosfamide (Ifex)

Synthetic analog of cyclophosphamide; cross-links DNA strands; inhibits DNA synthesis and protein synthesis.

Paclitaxel

Synthetic analog of cyclophosphamide; cross-links DNA strands; inhibits DNA synthesis and protein synthesis.

Fluorouracil (Adrucil)

A pyrimidine analog that inhibits DNA synthesis during S phase by inhibition of thymidylate synthetase.

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