Hematospermia

Updated: Feb 15, 2018
  • Author: Alexander D Tapper, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Overview

Practice Essentials

Hematospermia is defined as blood in the semen. While often perceived as having little significance, blood in the ejaculate can cause great concern to the men who experience it. The condition is common, with many episodes going unnoticed; therefore, the prevalence of hematospermia remains unknown.

Hematospermia is most commonly secondary to infectious or inflammatory etiology and follows a benign and self-limited course. [1]  As such, no further diagnostic workup is generally needed; however, in some patients, hematospermia may be the first indicator of other urologic diseases or systemic disorders (see DDx/Diagnostic Considerations).

The advent of newer imaging modalities, especially transrectal ultrasonography, has altered both the diagnosis and the treatment of hematospermia. In 2009, Aslam et al developed an algorithm to guide the management of these patients. [2]

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Background

Hematospermia has been written about for centuries. Hippocrates, Galen, Pare, Morgagni, and Fournier all commented on this condition. The first American report appeared in 1894, and Fletcher, [3] Leary, [4] Marshall, [5] and Ganabathi [6] have  published excellent contemporary reviews on the subject.

 

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Anatomy and Physiology

For an understanding of the causes of hematospermia, a working knowledge of the relevant anatomy of the ejaculatory complex is useful.

The seminal vesicles are androgen-dependent accessory organs that produce and store seminal fluid, which is essential to male fertility. The seminal vesicles are best studied ultrasonographically. Normal seminal vesicles are flat paired structures that lie cephalad to the prostate behind the bladder and have a bow-tie appearance on transverse imaging. They are symmetric, well-defined, saccular, elongated organs.

In its normal collapsed state, the center of the seminal vesicle is homogeneous, with areas of increased echogenicity corresponding to the folds of secretory epithelium. In the distended state, the wall is visibly composed of 2 distinct layers. 

The dimensions of the seminal vesicles vary with age, but not with the ejaculatory state. Upon transrectal ultrasonography (TRUS), the dimensions are estimated to be 30 ± 5 mm in length, 15 ± 4 mm in width, and 13.7 ± 3.7 mL in mean volume. The age of the patient and degree of prostate enlargement have been shown to cause variation in the size of the seminal vesicles.

The vasa deferentia act as conduits, carrying sperm between the epididymis and the ejaculatory ducts via the vasal ampullae. The vasal ampullae pass medially to the seminal vesicles and are best seen using transaxial TRUS views.

The seminal vesicles and vasal ampullae join together to form the ejaculatory duct. The ejaculatory duct travels through the prostate and enters the urethra at the level of the verumontanum. The junction between the seminal vesicle and the ejaculatory duct lies within the prostate and is difficult to see in a healthy unobstructed system. Small echodensities are frequently seen at the junction of the ejaculatory ducts and the verumontanum in the urethra. These areas provide useful landmarks and are thought to represent concretions within the periurethral glands surrounding the verumontanum.

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Epidemiology

Frequency

United States

The true prevalence of hematospermia is unknown. It is likely that many cases escape the patient's notice, and remain unrecognized and unreported.

Data collected after TRUS-guided biopsy of the prostate suggest that up to 36.3% of men undergoing removal of 6-15 cores develop postprocedure hematospermia. Increasing the number of cores did not significantly increase the frequency of hematospermia. [7] Other studies have found rates of hematospermia following TRUS-guided biopsy to be as high as 84%. [8]

Age

Hematospermia can occur in males of any age. In younger men (<40 y), hematospermia is uniformly benign. Even in older men, it is rarely associated with malignancy.

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