Hypovolemic Shock Medication

Updated: Oct 13, 2016
  • Author: Paul Kolecki, MD, FACEP; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
  • Print

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and prevent complications.


Antisecretory agents

Class Summary

These agents have vasoconstrictive properties and can reduce blood flow to portal systems.

Somatostatin (Zecnil)

Naturally occurring tetradecapeptide isolated from the hypothalamus and pancreatic and enteric epithelial cells. Diminishes blood flow to portal system because of vasoconstriction. Has similar effects as vasopressin but does not cause coronary vasoconstriction. Rapidly cleared from the circulation, with an initial half-life of 1-3 min.

Octreotide (Sandostatin)

Synthetic octapeptide. Compared to somatostatin, has similar pharmacological actions with greater potency and longer duration of action.

Used as adjunct to nonoperative management of secreting cutaneous fistulas of the stomach, duodenum, small intestine (jejunum and ileum), or pancreas.