Hypoparathyroidism in Emergency Medicine Medication

1. Shoback D. Clinical practice. Hypoparathyroidism. N Engl J Med. 2008 Jul 24. 359(4):391-403. [QxMD MEDLINE Link].

2. Bilezikian JP, Brandi ML, Cusano NE, et al. Management of hypoparathyroidism: present and future. J Clin Endocrinol Metab. 2016 Jun. 101(6):2313-24. [QxMD MEDLINE Link]. [Full Text].

3. Chandran M, Deftos LJ, Stuenkel CA, Haghighi P, Orloff LA. Thymic parathyroid carcinoma and postoperative hungry bone syndrome. Endocr Pract. 2003 Mar-Apr. 9(2):152-6. [QxMD MEDLINE Link].

4. Maeda SS, Fortes EM, Oliveira UM, Borba VC, Lazaretti-Castro M. Hypoparathyroidism and pseudohypoparathyroidism. Arq Bras Endocrinol Metabol. 2006 Aug. 50(4):664-73. [QxMD MEDLINE Link].

5. Pieringer H, Hatzl-Griesenhofer M, Shebl O, Wiesinger-Eidenberger G, Maschek W, Biesenbach G. Hypocalcemic tetany in the newborn as a manifestation of unrecognized maternal primary hyperparathyroidism. Wien Klin Wochenschr. 2007. 119(3-4):129-31. [QxMD MEDLINE Link].

6. Poomthavorn P, Ongphiphadhanakul B, Mahachoklertwattana P. Transient neonatal hypoparathyroidism in two siblings unmasking maternal normocalcemic hyperparathyroidism. Eur J Pediatr. 2008 Apr. 167(4):431-4. [QxMD MEDLINE Link].

7. Ip P. Neonatal convulsion revealing maternal hyperparathyroidism: an unusual case of late neonatal hypoparathyroidism. Arch Gynecol Obstet. 2003 Aug. 268(3):227-9. [QxMD MEDLINE Link].

8. Graber ML. Magnesium deficiency: pathophysiologic and clinical overview. Am J Kidney Dis. 1995 Jun. 25(6):973. [QxMD MEDLINE Link].

9. Garrahy A, Murphy MS, Sheahan P. Impact of postoperative magnesium levels on early hypocalcemia and permanent hypoparathyroidism after thyroidectomy. Head Neck. 2016 Apr. 38(4):613-9. [QxMD MEDLINE Link].

10. Kitsiou-Tzeli S, Kolialexi A, Mavrou A. Endocrine manifestations in DiGeorge and other microdeletion syndromes related to 22q11.2. Hormones (Athens). 2005 Oct-Dec. 4(4):200-9. [QxMD MEDLINE Link].

11. Courtens W, Wuyts W, Poot M, et al. Hypoparathyroidism-retardation-dysmorphism syndrome in a girl: a new variant not caused by a TBCE mutation--clinical report and review. Am J Med Genet A. 2006 Mar 15. 140(6):611-7. [QxMD MEDLINE Link].

12. Carpenter TO, Carnes DL Jr, Anast CS. Hypoparathyroidism in Wilson's disease. N Engl J Med. 1983 Oct 13. 309(15):873-7. [QxMD MEDLINE Link].

13. Brinkane A, Peschard S, Leroy-Terquem E, et al. [Rare association of hypoparathyroidism and mediastinal-pulmonary sarcoidosis]. Ann Med Interne (Paris). 2001 Feb. 152(1):63-4. [QxMD MEDLINE Link].

14. Kazaure HS, Sosa JA. Surgical hypoparathyroidism. Endocrinol Metab Clin North Am. 2018 Dec. 47 (4):783-96. [QxMD MEDLINE Link].

15. Powers J, Joy K, Ruscio A, Lagast H. Prevalence and incidence of hypoparathyroidism in the United States using a large claims database. J Bone Miner Res. 2013 Dec. 28(12):2570-6. [QxMD MEDLINE Link].

16. Abate EG, Clarke BL. Review of hypoparathyroidism. Front Endocrinol (Lausanne). 2016. 7:172. [QxMD MEDLINE Link]. [Full Text].

17. El Kawkgi OM, Li D, Kotwal A, Wermers RA. Hypoparathyroidism: an uncommon complication associated with immune checkpoint inhibitor therapy. Mayo Clin Proc Innov Qual Outcomes. 2020 Dec. 4 (6):821-5. [QxMD MEDLINE Link]. [Full Text].

18. Marcucci G, Cianferotti L, Parri S, et al. HypoparaNet: a database of chronic hypoparathyroidism based on expert medical-surgical centers in Italy. Calcif Tissue Int. 2018 Aug. 103 (2):151-63. [QxMD MEDLINE Link].

19. Clarke BL, Brown EM, Collins MT, et al. Epidemiology and diagnosis of hypoparathyroidism. J Clin Endocrinol Metab. 2016 Jun. 101(6):2284-99. [QxMD MEDLINE Link]. [Full Text].

20. Rajendram R, Deane JA, Barnes M, et al. Rapid onset childhood cataracts leading to the diagnosis of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Am J Ophthalmol. 2003 Nov. 136(5):951-2. [QxMD MEDLINE Link].

21. Abe S, Tojo K, Ichida K, et al. A rare case of idiopathic hypoparathyroidism with varied neurological manifestations. Intern Med. 1996 Feb. 35(2):129-34. [QxMD MEDLINE Link].

22. Chow KS, Lu DN. [Primary hypoparathyroidism with basal ganglia calcification: report of a case]. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1989 Mar-Apr. 30(2):129-33. [QxMD MEDLINE Link].

23. Hershkovitz E, Rozin I, Limony Y, et al. Hypoparathyroidism, retardation, and dysmorphism syndrome: impaired early growth and increased susceptibility to severe infections due to hyposplenism and impaired polymorphonuclear cell functions. Pediatr Res. 2007 Oct. 62(4):505-9. [QxMD MEDLINE Link].

24. Klingberg G, Dietz W, Oskarsdottir S, Odelius H, Gelander L, Noren JG. Morphological appearance and chemical composition of enamel in primary teeth from patients with 22q11 deletion syndrome. Eur J Oral Sci. 2005 Aug. 113(4):303-11. [QxMD MEDLINE Link].

25. Lam J, Maragano P, Lepez B, Vasquez L. [Hypocalcemic cardiomyopathy secondary to hypoparathyroidism after a thyroidectomy: report of one case]. Rev Med Chil. 2007 Mar. 135(3):359-64. [QxMD MEDLINE Link].

26. Tambyah PA, Ong BK, Lee KO. Reversible parkinsonism and asymptomatic hypocalcemia with basal ganglia calcification from hypoparathyroidism 26 years after thyroid surgery. Am J Med. 1993 Apr. 94(4):444-5. [QxMD MEDLINE Link].

27. Okazaki T, Takuwa Y, Yamamoto M, et al. Ossification of the paravertebral ligaments: a frequent complication of hypoparathyroidism. Metabolism. 1984 Aug. 33(8):710-3. [QxMD MEDLINE Link].

28. Harzy T, Benbouazza K, Amine B, Rahmouni R, Guedira N, Hajjaj-Hassouni N. Idiopathic hypoparathyroidism and adhesive capsulitis of the shoulder in two first-degree relatives. Joint Bone Spine. 2004 May. 71(3):234-6. [QxMD MEDLINE Link].

29. Kashyap AS, Padmaprakash KV, Kashyap S, Anand KP. Acute laryngeal spasm. Emerg Med J. Jan 2007. 24(1):66. [QxMD MEDLINE Link].

30. Christopher RH, David KV, Pricilla RA. Primary hypoparathyroidism presenting with new adult onset seizures in family practice. J Family Med Prim Care. 2014 Jul. 3(3):266-8. [QxMD MEDLINE Link]. [Full Text].

31. Langevitz P, Fichman B, Cabili S. Recurrent laryngospasm: a neglected symptom of hypoparathyroidism. South Med J. 1985 Nov. 78(11):1400. [QxMD MEDLINE Link].

32. Lehmann G, Deisenhofer I, Ndrepepa G, Schmitt C. ECG changes in a 25-year-old woman with hypocalcemia due to hypoparathyroidism. Hypocalcemia mimicking acute myocardial infarction. Chest. 2000 Jul. 118(1):260-2. [QxMD MEDLINE Link].

33. Ratanaanekchai T, Art-smart T, Vatanasapt P. Dysphagia after total laryngectomy resulting from hypocalcemia: case report. J Med Assoc Thai. 2004 Jun. 87(6):722-4. [QxMD MEDLINE Link].

34. Fuleihan Gel-H, Rubeiz N. Dermatologic manifestations of parathyroid-related disorders. Clin Dermatol. 2006 Jul-Aug. 24(4):281-8. [QxMD MEDLINE Link].

35. Kazmi AS, Wall BM. Reversible congestive heart failure related to profound hypocalcemia secondary to hypoparathyroidism. Am J Med Sci. 2007 Apr. 333(4):226-9. [QxMD MEDLINE Link].

36. Gupta RP, Krishnan RA, Kumar S, Beniwal S, Devaraja R, Kochar SK. A rare cause of heart failure--primary hypoparathyroidism. J Assoc Physicians India. 2007 Jul. 55:522-4. [QxMD MEDLINE Link].

37. Mavroudis K, Aloumanis K, Stamatis P, Antonakoudis G, Kifnidis K, Antonakoudis C. Irreversible end-stage heart failure in a young patient due to severe chronic hypocalcemia associated with primary hypoparathyroidism and celiac disease. Clin Cardiol. 2010 Feb. 33(2):E72-5. [QxMD MEDLINE Link].

38. Walton DM, Thomas DC, Aly HZ, Short BL. Morbid hypocalcemia associated with phosphate enema in a six-week-old infant. Pediatrics. 2000 Sep. 106(3):E37. [QxMD MEDLINE Link].

39. Ulozas E, Chebrolu SB, Shanaah A, Daoud TM, Leehey DJ, Ing TS. Symptomatic hypocalcemia due to the inadvertent use of a calcium-free hemodialysate. Artif Organs. 2004 Feb. 28(2):229-31. [QxMD MEDLINE Link].

40. Bastepe M. Genetics and epigenetics of parathyroid hormone resistance. Endocr Dev. 2013. 24:11-24. [QxMD MEDLINE Link].

41. Hermann M, Ott J, Promberger R, Kober F, Karik M, Freissmuth M. Kinetics of serum parathyroid hormone during and after thyroid surgery. Br J Surg. 2008 Dec. 95(12):1480-7. [QxMD MEDLINE Link].

42. Hayashida CY, Toledo SP, Barros MT, Ezabella MC, Laudanna AA. [Polyglandular autoimmune type I syndrome with hypoparathyroidism, chronic mucocutaneous candidiasis and intestinal malabsorption]. Rev Hosp Clin Fac Med Sao Paulo. 1990 Jan-Feb. 45(1):24-8. [QxMD MEDLINE Link].

43. Mangat JS, Till J, Bridges N. Hypocalcaemia mimicking long QT syndrome: case report. Eur J Pediatr. 2008 Feb. 167(2):233-5. [QxMD MEDLINE Link].

44. Laway BA, Goswami R, Singh N, Gupta N, Seith A. Pattern of bone mineral density in patients with sporadic idiopathic hypoparathyroidism. Clin Endocrinol (Oxf). 2006 Apr. 64(4):405-9. [QxMD MEDLINE Link].

45. Tecilazich F, Formenti AM, Frara S, Giubbini R, Giustina A. Treatment of hypoparathyroidism. Best Pract Res Clin Endocrinol Metab. 2018 Dec. 32 (6):955-64. [QxMD MEDLINE Link].

46. Trombetti A, Bégin MJ. [PTH-replacement therapy in hypoparathyroidism: what benefits?] [English, French]. Rev Med Suisse. 2021 Apr 21. 17 (735):788-92. [QxMD MEDLINE Link].

47. Khan AA, Rejnmark L, Rubin M, et al. PaTH forward: a randomized, double-blind, placebo-controlled phase 2 trial of TransCon PTH in adult hypoparathyroidism. J Clin Endocrinol Metab. 2022 Jan 1. 107 (1):e372-85. [QxMD MEDLINE Link].

48. [Guideline] Brandi ML, Bilezikian JP, Shoback D, et al. Management of hypoparathyroidism: summary statement and guidelines. J Clin Endocrinol Metab. 2016 Jun. 101(6):2273-83. [QxMD MEDLINE Link]. [Full Text].

49. [Guideline] Bollerslev J, Rejnmark L, Marcocci C, et al. European Society of Endocrinology Clinical Guideline: Treatment of chronic hypoparathyroidism in adults. Eur J Endocrinol. 2015 Aug. 173(2):G1-G20. [QxMD MEDLINE Link]. [Full Text].

50. [Guideline] Turner J, Gittoes N, Selby P, Society for Endocrinology Clinical Committee. Society for Endocrinology Endocrine emergency guidance: Emergency management of acute hypocalcaemia in adult patients. Endocr Connect. 2016 Sep. 5(5):G7-G8. [QxMD MEDLINE Link]. [Full Text].

51. Teaema FH, Al Ansari K. Nineteen cases of symptomatic neonatal hypocalcemia secondary to vitamin D deficiency: a 2-year study. J Trop Pediatr. 2010 Apr. 56(2):108-10. [QxMD MEDLINE Link].

52. Akkan T, Dagdeviren M, Koca AO, Ertugrul DT, Altay M. Alternate-day calcium dosing may be an effective treatment option for chronic hypoparathyroidism. J Endocrinol Invest. 2020 Jun. 43 (6):853-8. [QxMD MEDLINE Link].

53. Di Filippo L, Formenti AM, Rovere-Querini P, et al. Hypocalcemia is highly prevalent and predicts hospitalization in patients with COVID-19. Endocrine. 2020 Jun. 68 (3):475-8. [QxMD MEDLINE Link]. [Full Text].

54. García-Garcia E, Gomez-Gila AL, Romero-Lluch AR, et al. Hypoparathyroidism after thyroidectomy: a 20-year experience at a children's hospital. Endocrinol Diabetes Nutr (Engl Ed). 2021 Jul 13. [QxMD MEDLINE Link].

Andrew G Park, DO, MPH, FAWM Assistant Professor, Department of Emergency Medicine, Department of Preventative Medicine and Public Health, University of Kansas Medical Center

Andrew G Park, DO, MPH, FAWM is a member of the following medical societies: Wilderness Medical Society

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Howard A Bessen, MD Professor of Medicine, Department of Emergency Medicine, University of California, Los Angeles, David Geffen School of Medicine; Program Director, Harbor-UCLA Medical Center

Howard A Bessen, MD is a member of the following medical societies: American College of Emergency Physicians

Disclosure: Nothing to disclose.

Erik D Schraga, MD Staff Physician, Department of Emergency Medicine, Mills-Peninsula Emergency Medical Associates

Disclosure: Nothing to disclose.

Agnieszka Gliwa, MD Assistant Professor of Medicine, State University of New York Downstate Medical Center College of Medicine, Brooklyn; Attending Physican and Endocrinologist, Staten Island University Hospital

Agnieszka Gliwa, MD is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians-American Society of Internal Medicine, American Medical Association, Endocrine Society

Disclosure: Nothing to disclose.

David J Wallace, MD, MPH Critical Care Medicine Fellow, University of Pittsburgh Medical Center

David J Wallace, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, American College of Emergency Physicians, and Society of Critical Care Medicine

Disclosure: Nothing to disclose.

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