Caterpillar Envenomation

Updated: Jul 18, 2022
  • Author: Andrew G Park, DO, MPH, FAWM; Chief Editor: Joe Alcock, MD, MS  more...
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Practice Essentials

More than 165,000 species of caterpillars in the order Lepidoptera (phylum Arthropoda, class Insecta) exist. About 150 are of medical importance due to their ability to induce an irritant or toxic dermatitis in humans and the ability of some species to sting. Caterpillars are the larval forms of moths and butterflies. After hatching from their eggs, caterpillars pass through 4-5 instars (stages between molts) before they pupate in a cocoon. The adult moth or butterfly emerges from the cocoon to reproduce the next generation. More than 50 species in the United States alone are capable of inflicting a painful sting. Seasonal epidemics of dermatitis can occur when caterpillars are numerous.

The most dangerous caterpillar in the United States is the puss caterpillar or asp (Megalopyge opercularis; shown in the image below), the larval form of the flannel moth. It is found throughout the Southeast, from Maryland to Mexico. It is especially prevalent in Florida, Louisiana, and Texas. Stings from this species are common from June through October. [1]

Caterpillar envenomations. Puss caterpillar or asp Caterpillar envenomations. Puss caterpillar or asp. Photo courtesy of the Arizona Poison and Drug Information Center.


Laboratory studies are generally not required for caterpillar stings unless evidence of coagulopathy is present, as in some New World caterpillars in the family Saturniidae (Lonomia species). Those that may be warranted include the following:

  • Hematology: CBC
  • Coagulation studies: Prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen level, fibrin degradation products, D-dimer assay, urine bedside test for blood
  • Renal function studies: Creatinine, BUN

A chest radiograph is reasonable if the patient has significant respiratory symptoms.


See Prehospital Care and Emergency Department Care.


Consultations usually are not necessary following most caterpillar contacts. An ophthalmologist should be promptly consulted if ocular involvement is present. [2]  Repeated ophthalmologic intervention to remove embedded hairs may be necessary. [3]



Human disease from caterpillars or moths usually arises from direct contact, exposure to substances or animals that have been infested with caterpillars or their webs, or contact with airborne caterpillar debris.

Diaz classifies the diseases caused by caterpillars into 5 groups: erucism, lepidopterism, dendrolimiasis, ophthalmia nodosa, and consumptive coagulopathy with secondary fibrinolysis.

Erucism (caterpillar dermatitis) is characterized by a localized, pruritic, maculopapular contact dermatitis and urticaria, and follows contact with toxic hairs, spines, or hemolymph, either directly or following aerosolization.

Lepidopterism is a systemic illness that occurs following such contact, and it is typified by diffuse urticaria, upper airway inflammation, nausea, vomiting, headache, and bronchospasm.

Dendrolimiasis is a more chronic illness that follows contact with the Asian Dendorlimus pini caterpillar. Patients with this disorder demonstrate a pruritic maculopapular rash and migratory polyarthritis/polychondritis, which can progress to chronic osteoarthritis. Occasionally, acute scleritis occurs as well.

Ophthalmia nodosa presents with acute conjunctivitis, progressing to panophthalmitis, following penetration of the cornea by urticating hairs. There has also been a report of caterpillar setae penetrating into multiple meibomian gland orifices. [4]

Consumptive coagulopathy with secondary fibrinolysis occurs most commonly following stings by the South American Lonomia caterpillar whose venom activates factor X and prothrombin. Patients can demonstrate bleeding from almost any anatomic site and may develop acute (and possibly chronic) renal failure.

Caterpillar venoms are produced by glandular cells in the epithelium and are stored in and injected by urticating hairs and spines (setae). Some species produce toxic hemolymph, which can cause human disease.

In some patients, immunoglobulin E (IgE) antibodies are produced following contact, resulting in a hypersensitive state and the production of generalized urticaria on subsequent re-contact. A few caterpillars lacking urticating hairs are capable of inducing a contact dermatitis (type IV hypersensitivity).

Some caterpillars and moths release their toxic hairs into the environment, where the hairs can be inhaled. Pets or contaminated objects also can carry venomous hairs. In any of these situations, contact with the hairs can cause rhinitis or respiratory disease. Seasonal epidemics of respiratory disease have occurred in Latin America because of this phenomenon. The pathologic response leading to erucism or lepidopterism consists of acute inflammation and cellular infiltration around hairs that have penetrated the skin or conjunctiva or have been inhaled into the respiratory tract.

In the skin, diffuse vascular dilatation occurs, with subsequent edema formation in the superficial dermis and ballooning of keratinocytes within the epidermis that can lead to vesiculation. In the eye, hairs have a remarkable penetrating capacity and may work their way into the cornea, anterior chamber, or lens, where an intense inflammatory response occurs secondary to the nature of the foreign material and direct toxic effects.

Caterpillar venom-filled spines, found only in the larval forms (adult moths and butterflies do not sting), are hollow structures with a single basal poison cell that produces toxin. When pressed into human skin, the tip of the spine fractures, and the venom is injected under pressure. Toxicity declines significantly after the creature's death, but irritant or toxic hairs may retain the ability to cause dermatitis for years. Likewise, the toxic hemolymph of some caterpillars retains its potency for prolonged periods after the animal's death.

Caterpillar venoms are poorly studied but may contain peptides, hyaluronidase, phospholipase A, and biogenic amines such as histamine or histamine-releasing substances. Some, such as the South American Lonomia species, contain fibrinolytic proteases and coagulation activators that can stimulate a consumptive coagulopathy and renal failure in victims.



Although no accurate information is available, epidemics of erucism and lepidopterism have been reported in the United States. These include school closings, outbreaks of dermatitis and rhinitis in the thousands, and symptoms in more than 500,000 people caused by airborne caterpillar hair dispersion. In Texas, there were 3484 stings from the M opercularis caterpillar reported to poison centers from 2000-2016. Stings were most frequently reported during October and November, and 89% of patients did not require management in a healthcare facility. [5]

Little accurate information is available on the number of international cases, though it appears that the incidence of human disease is increasing. The Brazilian Ministry of Health reported 60,588 caterpillar envenomation cases from 2000-2018 or 3.2 cases per 100,000 inhabitants. Of these, 33 cases were fatalities. [6]  

Children, being prone to want to play with caterpillars, may be at increased risk of exposure.



The prognosis is generally excellent.

Occasional case reports of death from erucism exist, but death is very rare following stings by most species. Death may be secondary to a hypersensitivity reaction or bleeding diathesis in cases involving caterpillars of the Saturniidae family. In this family, South American Lonomia caterpillars have a high fatality rate (approximately 1.7%) due to the toxicity of their venoms and the fact that many exposures lead to multiple stings due to the communal nature of these species. No deaths have been reported following M opercularis stings.

Reported complications include panophthalmitis, consumptive coagulopathy, intracranial hemorrhage, renal failure, and osteochondritis.