Spinal Cord Neoplasms Medication

Updated: Jul 17, 2019
  • Author: Jesse Borke, MD, FACEP, FAAEM; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Medication Summary

Dexamethasone administration may acutely preserve neurologic function in patients with epidural spinal cord compression. Opinions regarding dosages vary but recent reviews have recommended doses from 10 to 16 mg, administered either intravenously or orally (IV is more common), followed by 16 mg/day. [9, 10]



Class Summary

These agents have anti-inflammatory properties and cause profound and varied metabolic effects. In addition, they modify the body's immune response to diverse stimuli. With therapy, tumor-associated edema and cord compression, particularly those caused by metastatic tumors, may diminish.

Dexamethasone (Decadron, Hexadrol)

Dexamethasone is used in the treatment of various inflammatory diseases. The mechanism of action in neurologic function is not completely understood. Some physicians prefer higher-dose regimens (100 mg initial bolus), although this has waned in popularity.