Chancroid in Emergency Medicine Guidelines

Updated: Jan 04, 2023
  • Author: Kristine Song, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Guidelines Summary

Per CDC guidelines (2015), a diagnosis of chancroid requires satisfaction of all of the following conditions [13] :

  • The patient has one or more painful genital ulcers.
  • The clinical presentation, appearance of genital ulcers, and, if present, regional lymphadenopathy are typical of chancroid.
  • The patient has no evidence of  T pallidum infection on darkfield examination of ulcer exudate or on a serologic test for syphilis performed at least 7 days after the onset of ulcers.
  • The HSV PCR test or HSV culture results performed on the ulcer exudate are negative.

CDC treatment guidelines for chancroid recommend one of the following options [13] :

  • Azithromycin 1 g orally as a single dose
  • Ceftriaxone 250 mg IM as a single dose
  • Ciprofloxacin 500 mg orally twice a day for 3 days
  • Erythromycin base 500 mg orally three times a day for 7 days