Herpes Simplex Virus (HSV) in Emergency Medicine Treatment & Management

1. Mell HK. Management of oral and genital herpes in the emergency department. Emerg Med Clin North Am. 2008 May. 26(2):457-73, x. [Medline].

2. Tronstein E, Johnston C, Huang ML, Selke S, Magaret A, Warren T, et al. Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection. JAMA. 2011 Apr 13. 305 (14):1441-9. [Medline].

3. Fanfair RN, Zaidi A, Taylor LD, Xu F, Gottlieb S, Markowitz L. Trends in seroprevalence of herpes simplex virus type 2 among non-Hispanic blacks and non-Hispanic whites aged 14 to 49 years--United States, 1988 to 2010. Sex Transm Dis. 2013 Nov. 40 (11):860-4. [Medline].

4. Wald A, Corey L. Persistence in the population: epidemiology, transmission. Arvin A, Campadelli-Fiume G, Mocarski E, Moore PS, Roizman B, Whitley R, Yamanishi K, eds. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge, MA: Cambridge University Press; 2007.

5. World Health Organization. Herpes simplex virus. Available at http://www.who.int/mediacentre/factsheets/fs400/en/. Jan 2017; Accessed: April 2017.

6. Porter D. Herpes Keratitis. American Academy of Ophthalmology Herpes Keratitis. Available at https://www.aao.org/eye-health/diseases/herpes-keratitis. April 25, 2018; Accessed: July 9, 2019.

7. Biggs WS, Williams RM. Common gynecologic infections. Prim Care. 2009 Mar. 36(1):33-51, viii. [Medline].

8. Ahmad FA, Storch GA, Miller AS. Impact of an Institutional Guideline on the Care of Neonates at Risk for Herpes Simplex Virus in the Emergency Department. Pediatr Emerg Care. 2015 Aug 21. [Medline].

9. Amel Jamehdar S, Mammouri G, Sharifi Hoseini MR, Nomani H, Afzalaghaee M, Boskabadi H, et al. Herpes simplex virus infection in neonates and young infants with sepsis. Iran Red Crescent Med J. 2014 Feb. 16 (2):e14310. [Medline].

10. Bernstein DI, Bellamy AR, Hook EW 3rd, Levin MJ, Wald A, Ewell MG, et al. Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women. Clin Infect Dis. 2013 Feb. 56 (3):344-51. [Medline].

11. Tronstein E, Johnston C, Huang ML, Selke S, Magaret A, Warren T, et al. Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection. JAMA. 2011 Apr 13. 305(14):1441-9. [Medline].

12. Corey L, Wald A. Genital Herpes. Holmes KK, Sparling PF, Stamm WE, et al. Sexually Transmitted Diseases. 4th ed. New York: McGraw-Hill; 2008. 399-437.

13. Singh A, Preiksaitis J, Ferenczy A, Romanowski B. The laboratory diagnosis of herpes simplex virus infections. Can J Infect Dis Med Microbiol. 2005 Mar. 16 (2):92-8. [Medline].

14. Brown ZA, Wald A, Morrow RA, Selke S, Zeh J, Corey L. Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant. JAMA. 2003 Jan 8. 289 (2):203-9. [Medline].

15. Workowski KA, Bolan GA, Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015 Jun 5. 64 (RR-03):1-137. [Medline].

16. World Health Organization. WHO Guidelines for the treatment of Genital Herpes Simplex Virus. Geneva, Switzerland: World Health Organization; 2016. [Full Text].

17. Gnann JW Jr, Whitley RJ. CLINICAL PRACTICE. Genital Herpes. N Engl J Med. 2016 Aug 18. 375 (7):666-74. [Medline].

18. Frenkl TL, Potts J. Sexually transmitted infections. Urol Clin North Am. 2008 Feb. 35(1):33-46; vi. [Medline].

19. Bucher J, Koyfman A. What Is the Most Effective Treatment of Herpes Simplex Keratitis?. Ann Emerg Med. 2016 Jul. 68 (1):26-7. [Medline].

20. Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA. 2010 Aug 25. 304(8):859-66. [Medline].

21. Kaminester LH, Pariser RJ, Pariser DM, Weiss JS, Shavin JS, Landsman L, et al. A double-blind, placebo-controlled study of topical tetracaine in the treatment of herpes labialis. J Am Acad Dermatol. 1999 Dec. 41 (6):996-1001. [Medline].

22. [Guideline] Workowski KA, Berman SM. Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm Rep. 2006 Aug 4. 55:1-94. [Medline].

23. Johnson R. Herpes gladiatorum and other skin diseases. Clin Sports Med. 2004 Jul. 23(3):473-84, x. [Medline].

24. Benedetti J, Corey L, Ashley R. Recurrence rates in genital herpes after symptomatic first-episode infection. Ann Intern Med. 1994 Dec 1. 121(11):847-54. [Medline].

25. Clark JL, Tatum NO, Noble SL. Management of genital herpes. Am Fam Physician. 1995 Jan. 51(1):175-82, 187-8. [Medline].

26. Cockerell C. Diagnosis and treatment of cutaneous herpes simplex virus infections. West J Med. 1996 Jun. 164(6):518-20. [Medline].

27. Hill J, Roberts S. Herpes simplex virus in pregnancy: new concepts in prevention and management. Clin Perinatol. 2005 Sep. 32(3):657-70. [Medline].

28. Hirsch MS. Herpes simplex virus. Mandell GL, ed. Mandell, Douglas, and Bennet's Principles and Practice of Infectious Diseases. 4th ed. Churchill Livingstone; 1995. 1336-45.

29. Holland-Hall C. Sexually transmitted infections: screening, syndromes, and symptoms. Prim Care. 2006 Jun. 33(2):433-54. [Medline].

30. Patel R, Rompalo A. Managing patients with genital herpes and their sexual partners. Infect Dis Clin North Am. 2005 Jun. 19(2):427-38, x. [Medline].

31. Rooney JF, Straus SE, Mannix ML. Oral acyclovir to suppress frequently recurrent herpes labialis. A double-blind, placebo-controlled trial. Ann Intern Med. 1993 Feb 15. 118(4):268-72. [Medline].

32. Whitley RJ, Gnann JW Jr. Acyclovir: a decade later. N Engl J Med. 1992 Sep 10. 327(11):782-9. [Medline].

33. Wu JJ, Pang KR, Huang DB. Advances in antiviral therapy. Dermatol Clin. 2005 Apr. 23(2):313-22. [Medline].

34. Patel EU, Frank MA, Hsieh YH, Rothman RE, Baker AE, Kraus CK, et al. Prevalence and factors associated with herpes simplex virus type 2 infection in patients attending a Baltimore City emergency department. PLoS One. 2014. 9 (7):e102422. [Medline].

Melissa Kohn, MD, MS, FACEP, EMT-PHP Clinical Instructor of Emergency Medicine, Sidney Kimmel Medical College of Thomas Jefferson University; Emergency Medicine/EMS Physician, Director of EMS Resident Education, Medical Command Facility Director, Einstein Medical Center

Melissa Kohn, MD, MS, FACEP, EMT-PHP is a member of the following medical societies: American College of Emergency Physicians, National Association of EMS Physicians

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Eric L Weiss, MD, DTM&H Medical Director, Office of Service Continuity and Disaster Planning, Fellowship Director, Stanford University Medical Center Disaster Medicine Fellowship, Chairman, SUMC and LPCH Bioterrorism and Emergency Preparedness Task Force, Clinical Associate Professor, Department of Surgery (Emergency Medicine), Stanford University Medical Center

Eric L Weiss, MD, DTM&H is a member of the following medical societies: American College of Emergency Physicians, American College of Occupational and Environmental Medicine, American Medical Association, American Society of Tropical Medicine and Hygiene, Physicians for Social Responsibility, Southeastern Surgical Congress, Southern Oncology Association of Practices, Southern Clinical Neurological Society, Wilderness Medical Society

Disclosure: Nothing to disclose.

Steven C Dronen, MD, FAAEM Chair, Department of Emergency Medicine, LeConte Medical Center

Steven C Dronen, MD, FAAEM is a member of the following medical societies: American Academy of Emergency Medicine, Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Lawrence C Brilliant, MD Clinical Assistant Professor, Department of Primary Care and Community Services, MCP Hahnemann University; Attending Physician, Department of Emergency Medicine, Doylestown Hospital

Lawrence C Brilliant, MD is a member of the following medical societies: American College of Emergency Physicians

Disclosure: Nothing to disclose.

Robin R Hemphill, MD, MPH Associate Professor, Director, Quality and Safety, Department of Emergency Medicine, Emory University School of Medicine

Robin R Hemphill, MD, MPH is a member of the following medical societies: American College of Emergency Physicians, Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Rahul Sharma, MD, MBA, FACEP Medical Director and Associate Chief of Service, NYU Langone Medical Center, Tisch Hospital Emergency Department; Assistant Professor of Emergency Medicine, New York University School of Medicine

Rahul Sharma, MD, MBA, FACEP is a member of the following medical societies: American College of Emergency Physicians, American Association for Physician Leadership, Phi Beta Kappa, Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

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