Infectious Mononucleosis (IM) in Emergency Medicine Medication

Updated: Nov 11, 2022
  • Author: Michael S Omori, MD; Chief Editor: Gil Z Shlamovitz, MD, FACEP  more...
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Medication Summary

The treatment of infectious mononucleosis is largely supportive except when coexisting complications may indicate the use of corticosteroids.



Class Summary

These agents are recommended in patients with severe edema of the Waldeyer ring with potential for airway obstruction, autoimmune hemolytic anemia, severe thrombocytopenia, or significant involvement of the heart or CNS.

Prednisone (Deltasone, Orasone, Sterapred)

Useful in the treatment of inflammatory and autoimmune reactions. By reversing increased capillary permeability and suppressing PMN activity, it may decrease inflammation. The routine use of prednisone in patients with uncomplicated IM is not recommended. Generally is reserved for patients with significant symptoms or complications.