Trichinellosis/Trichinosis Differential Diagnoses

1. Zarlenga DS, Rosenthal BM, La Rosa G, Pozio E, Hoberg EP. Post-Miocene expansion, colonization, and host switching drove speciation among extant nematodes of the archaic genus Trichinella. Proc Natl Acad Sci U S A. 2006 May 9. 103(19):7354-9. [QxMD MEDLINE Link].

2. Pozio E, Zarlenga DS. Recent advances on the taxonomy, systematics and epidemiology of Trichinella. Int J Parasitol. 2005 Oct. 35(11-12):1191-204. [QxMD MEDLINE Link].

3. Neghina R, Moldovan R, Marincu I, Calma CL, Neghina AM. The roots of evil: the amazing history of trichinellosis and Trichinella parasites. Parasitol Res. 2012 Feb. 110(2):503-8. [QxMD MEDLINE Link].

4. [Guideline] Dupouy-Camet, Bruschi F. Management and Diagnosis of Human Trichinellosis. FAO/WHO/OIE Guidelines for the Surveillance, Prevention, and Control of Trichinellosis. Trichinellosis.org. Available at http://www.trichinellosis.org/uploads/FAO-WHO-OIE_Guidelines.pdf.. Accessed: 28 June, 2012.

5. Despommier D. The history of Trichinella. The Trichinella Page. Available at http://www.trichinella.org/index.htm. Accessed: November 2, 2007.

6. Cook GC. Outbreak of trichinosis (trichiniasis)-contracted in London in 1879. Postgrad Med J. 2001 Jan. 77(903):62-3. [QxMD MEDLINE Link].

7. Pozio E. Factors affecting the flow among domestic, synanthropic and sylvatic cycles of Trichinella. Vet Parasitol. 2000 Dec 1. 93(3-4):241-62. [QxMD MEDLINE Link].

8. Despommier D. Biology of the Nurse Cell — Parasite Complex. The Trichinella Page. Available at http://www.trichinella.org/bio_nursecell.htm. Accessed: 3 November, 2007.

9. Dabrowska M, Skoneczny M, Zielinski Z, Rode W. Nurse cell of Trichinella spp. as a model of long-term cell cycle arrest. Cell Cycle. 2008 Jul 15. 7(14):2167-78. [QxMD MEDLINE Link].

10. Wu Z, Sofronic-Milosavljevic Lj, Nagano I, Takahashi Y. Trichinella spiralis: nurse cell formation with emphasis on analogy to muscle cell repair. Parasit Vectors. 2008. 1(1):27. [QxMD MEDLINE Link].

11. Pozio E, Bruschi F. The importance of correct terminology in describing the muscular stage of Trichinella infection. Trends Parasitol. 2001 Aug. 17(8):362. [QxMD MEDLINE Link].

12. Fourestie V, Douceron H, Brugieres P, Ancelle T, Lejonc JL, Gherardi RK. Neurotrichinosis. A cerebrovascular disease associated with myocardial injury and hypereosinophilia. Brain. 1993 Jun. 116 (Pt 3):603-16. [QxMD MEDLINE Link].

13. Wilson NO, Hall RL, Montgomery SP, Jones JL. Trichinellosis surveillance--United States, 2008-2012. MMWR Surveill Summ. 2015 Jan 16. 64 Suppl 1:1-8. [QxMD MEDLINE Link]. [Full Text].

14. Roy SL, Lopez AS, Schantz PM. Trichinellosis surveillance--United States, 1997-2001. MMWR Surveill Summ. 2003 Jul 25. 52(6):1-8. [QxMD MEDLINE Link].

15. Graves T, Harkess J, Crutcher JM. Case report: locally acquired trichinosis in an immigrant from Southeast Asia. J Okla State Med Assoc. 1996 Nov. 89(11):402-4. [QxMD MEDLINE Link].

16. van Knapen F. Control of trichinellosis by inspection and farm management practices. Vet Parasitol. 2000 Dec 1. 93(3-4):385-92. [QxMD MEDLINE Link].

17. Pozio E. Trichinellosis in the European union: epidemiology, ecology and economic impact. Parasitol Today. 1998 Jan. 14(1):35-8. [QxMD MEDLINE Link].

18. Gamble HR, Brady RC, Bulaga LL, et al. Prevalence and risk association for Trichinella infection in domestic pigs in the northeastern United States. Vet Parasitol. 1999 Mar 22. 82(1):59-69. [QxMD MEDLINE Link].

19. Prescribed treatment of pork and products containing pork to destroy trichinae. United States Code of Federal Regulations. Accessed November 2, 2007: 9 CFR 318.10 (Rev 1/1/2007): [Full Text].

20. Pyburn DG, Gamble HR, Wagstrom EA, Anderson LA, Miller LE. Trichinae certification in the United States pork industry. Vet Parasitol. 2005 Sep 5. 132(1-2):179-83. [QxMD MEDLINE Link].

21. Murrell KD, Pozio E. Worldwide occurrence and impact of human trichinellosis, 1986-2009. Emerg Infect Dis. 2011 Dec. 17(12):2194-202. [QxMD MEDLINE Link].

22. Murrell KD, Pozio E. Trichinellosis: the zoonosis that won't go quietly. Int J Parasitol. 2000 Nov. 30(12-13):1339-49. [QxMD MEDLINE Link].

23. Dupouy-Camet J. Trichinellosis: a worldwide zoonosis. Vet Parasitol. 2000 Dec 1. 93(3-4):191-200. [QxMD MEDLINE Link].

24. Pozio E. New patterns of Trichinella infection. Vet Parasitol. 2001 Jul 12. 98(1-3):133-48. [QxMD MEDLINE Link].

25. Gajadhar AA, Gamble HR. Historical perspectives and current global challenges of Trichinella and trichinellosis. Vet Parasitol. 2000 Dec 1. 93(3-4):183-9. [QxMD MEDLINE Link].

26. Gamble HR, Bessonov AS, Cuperlovic K, et al. International Commission on Trichinellosis: recommendations on methods for the control of Trichinella in domestic and wild animals intended for human consumption. Vet Parasitol. 2000 Dec 1. 93(3-4):393-408. [QxMD MEDLINE Link].

27. Kaewpitoon N, Kaewpitoon SJ, Pengsaa P. Food-borne parasitic zoonosis: distribution of trichinosis in Thailand. World J Gastroenterol. 2008 Jun 14. 14(22):3471-5. [QxMD MEDLINE Link]. [Full Text].

28. Watt G, Saisorn S, Jongsakul K, Sakolvaree Y, Chaicumpa W. Blinded, placebo-controlled trial of antiparasitic drugs for trichinosis myositis. J Infect Dis. 2000 Jul. 182(1):371-4. [QxMD MEDLINE Link].

29. Kurup A, Yew WS, San LM, Ang B, Lim S, Tai GK. Outbreak of suspected trichinosis among travelers returning from a neighboring island. J Travel Med. 2000 Jul-Aug. 7(4):189-93. [QxMD MEDLINE Link].

30. Centers for Disease Control and Prevention. Trichinellosis outbreaks--Northrhine-Westfalia, Germany, 1998-1999. MMWR Morb Mortal Wkly Rep. 1999 Jun 18. 48(23):488-92. [QxMD MEDLINE Link]. [Full Text].

31. Kramme S, Schmiedel S. Trichinellosis imported to Germany from Poland, cardiac complications. International Commission on Trichinellosis News Postings. 2007 Accessed: 15 August, 2007. [Full Text].

32. World Health Organization. Imported human outbreak of trichinellosis, Italy. Wkly Epidemiol Rec. 2001 Mar 30. 76(13):97-8. [QxMD MEDLINE Link]. [Full Text].

33. Samuelsson S, ed. Outbreak of trichinosis. Epi-News. 2004; 14. Staten Serum Institute. Available at http://www.ssi.dk/sw10275.asp. Accessed: 15 October, 2007.

34. Dupouy-Camet J. Trichinellosis: still a concern for Europe. Euro Surveill. 2006. 11(1):5. [QxMD MEDLINE Link]. [Full Text].

35. Neghina R. Trichinellosis, a Romanian never-ending story. An overview of traditions, culinary customs, and public health conditions. Foodborne Pathog Dis. 2010 Sep. 7(9):999-1003. [QxMD MEDLINE Link].

36. Kapel CM. Changes in the EU legislation on Trichinella inspection.

37. Neghina R, Neghina AM, Marincu I, Moldovan R, Iacobiciu I. Epidemiological and diagnostic findings during a 16-year-long trichinellosis surveillance in Timis County, Romania. Vet Parasitol. 2009 Feb 23. 159(3-4):328-31. [QxMD MEDLINE Link].

38. Papatsiros VG, Boutsini S, Ntousi D, et al. Detection and zoonotic potential of Trichinella spp. from free-range pig farming in Greece. Foodborne Pathog Dis. 2012 Jun. 9(6):536-40. [QxMD MEDLINE Link].

39. Akkoc N, Kuruuzum Z, Akar S, et al. A large-scale outbreak of trichinellosis caused by Trichinella britovi in Turkey. Zoonoses Public Health. 2009 Mar. 56(2):65-70. [QxMD MEDLINE Link].

40. Boireau P, Vallee I, Roman T, et al. Trichinella in horses: a low frequency infection with high human risk. Vet Parasitol. 2000 Dec 1. 93(3-4):309-20. [QxMD MEDLINE Link].

41. Liu M, Boireau P. Trichinellosis in China: epidemiology and control. Trends Parasitol. 2002 Dec. 18(12):553-6. [QxMD MEDLINE Link].

42. Takahashi Y, Mingyuan L, Waikagul J. Epidemiology of trichinellosis in Asia and the Pacific Rim. Vet Parasitol. 2000 Dec 1. 93(3-4):227-39. [QxMD MEDLINE Link].

43. Cui J, Wang ZQ, Kennedy MW. The re-emergence of trichinellosis in China?. Trends Parasitol. 2006 Feb. 22(2):54-5. [QxMD MEDLINE Link].

44. Uspensky A, Bukina L, Odoevskaya I, Movsesyan S, Voronin M. The epidemiology of trichinellosis in the Arctic territories of a Far Eastern District of the Russian Federation. J Helminthol. 2018 Jan 31. 1-8. [QxMD MEDLINE Link].

45. Springer YP, Casillas S, Helfrich K, Mocan D, Smith M, Arriaga G, et al. Two Outbreaks of Trichinellosis Linked to Consumption of Walrus Meat - Alaska, 2016-2017. MMWR Morb Mortal Wkly Rep. 2017 Jul 7. 66 (26):692-696. [QxMD MEDLINE Link]. [Full Text].

46. Proulx JF, MacLean JD, Gyorkos TW, et al. Novel prevention program for trichinellosis in inuit communities. Clin Infect Dis. 2002 Jun 1. 34(11):1508-14. [QxMD MEDLINE Link].

47. O'Brien F. Environmental health in the Canadian arctic of Nunavut: Our People - Our Land. Environment and Health International. 6(1):6-10. [Full Text].

48. Gallardo MT, Mateos L, Artieda J, et al. Outbreak of trichinellosis in Spain and Sweden due to consumption of wild boar meat contaminated with Trichinella britovi. Euro Surveill. 2007 Mar 15. 12(3):E070315.1. [QxMD MEDLINE Link].

49. Pozio E, Darwin Murrell K. Systematics and epidemiology of trichinella. Adv Parasitol. 2006. 63:367-439. [QxMD MEDLINE Link].

50. Gebreyes WA, Bahnson PB, Funk JA, McKean J, Patchanee P. Seroprevalence of Trichinella, Toxoplasma, and Salmonella in antimicrobial-free and conventional swine production systems. Foodborne Pathog Dis. 2008 Apr. 5(2):199-203. [QxMD MEDLINE Link].

51. van der Giessen J, Fonville M, Bouwknegt M, Langelaar M, Vollema A. Seroprevalence of Trichinella spiralis and Toxoplasma gondii in pigs from different housing systems in The Netherlands. Vet Parasitol. 2007 Sep 30. 148(3-4):371-4. [QxMD MEDLINE Link].

52. Müller N, Sager H, Schuppers M, Gottstein B. [Methods for investigating Trichinella infections in domestic and wild animals]. Schweiz Arch Tierheilkd. 2006 Sep. 148(9):463-71. [QxMD MEDLINE Link].

53. Owen IL, Pozio E, Tamburrini A, et al. Focus of human trichinellosis in Papua New Guinea. Am J Trop Med Hyg. 2001 Nov. 65(5):553-7. [QxMD MEDLINE Link].

54. Nuñez GG, Costantino SN, Gentile T, Venturiello SM. Immunoparasitological evaluation of Trichinella spiralis infection during human pregnancy: a small case series. Trans R Soc Trop Med Hyg. 2008 Jul. 102(7):662-8. [QxMD MEDLINE Link].

55. Webster P, Kapel CM. Studies on vertical transmission of Trichinella spp. in experimentally infected ferrets (Mustela putorius furo), foxes (Vulpes vulpes), pigs, guinea pigs and mice. Vet Parasitol. 2005 Jun 30. 130(3-4):255-62. [QxMD MEDLINE Link].

56. Dubinsky P, Boor A, Kincekova J, Tomasovicova O, Reiterova K, Bielik P. Congenital trichinellosis? Case report. Parasite. 2001 Jun. 8(2 Suppl):S180-2. [QxMD MEDLINE Link].

57. Dalcin D, Zarlenga DS, Larter NC, Hoberg E, Boucher DA, Merrifield S, et al. Trichinella Nativa Outbreak With Rare Thrombotic Complications Associated With Meat From a Black Bear Hunted in Northern Ontario. Clin Infect Dis. 2017 May 15. 64 (10):1367-1373. [QxMD MEDLINE Link].

58. Akar S, Gurler O, Pozio E, Onen F, Sari I, Gerceker E, et al. Frequency and severity of musculoskeletal symptoms in humans during an outbreak of trichinellosis caused by Trichinella britovi. J Parasitol. 2007 Apr. 93(2):341-4. [QxMD MEDLINE Link].

59. Nikolic S, Vujosevic M, Sasic M, et al. [Neurologic manifestations in trichinosis]. Srp Arh Celok Lek. 1998 May-Jun. 126(5-6):209-13. [QxMD MEDLINE Link].

60. Walsh DS, Jongsakul K, Watt G. Hand rash in trichinosis. Clin Exp Dermatol. 2001 May. 26(3):272-3. [QxMD MEDLINE Link].

61. Astudillo LM, Arlet PM. Images in clinical medicine. The chemosis of trichinosis. N Engl J Med. 2004 Jul 29. 351(5):487. [QxMD MEDLINE Link].

62. Bruschi F, Murrell KD. New aspects of human trichinellosis: the impact of new Trichinella species. Postgrad Med J. 2002 Jan. 78(915):15-22. [QxMD MEDLINE Link].

63. Pozio E, Foggin CM, Gelanew T, et al. Trichinella zimbabwensis in wild reptiles of Zimbabwe and Mozambique and farmed reptiles of Ethiopia. Vet Parasitol. 2007 Feb 28. 143(3-4):305-10. [QxMD MEDLINE Link].

64. Pozio E, Foggin CM, Gelanew T, Marucci G, Hailu A, Rossi P, et al. Trichinella zimbabwensis in wild reptiles of Zimbabwe and Mozambique and farmed reptiles of Ethiopia. Vet Parasitol. 2007 Feb 28. 143(3-4):305-10. [QxMD MEDLINE Link].

65. Kociecka W. Trichinellosis: human disease, diagnosis and treatment. Vet Parasitol. 2000 Dec 1. 93 (3-4):365-83. [QxMD MEDLINE Link].

66. Yera H, Andiva S, Perret C, Limonne D, Boireau P, Dupouy-Camet J. Development and evaluation of a Western blot kit for diagnosis of human trichinellosis. Clin Diagn Lab Immunol. 2003 Sep. 10(5):793-6. [QxMD MEDLINE Link].

67. Robert F, Weil B, Kassis N, Dupouy-Camet J. Investigation of immunofluorescence cross-reactions against Trichinella spiralis by western blot (immunoblot) analysis. Clin Diagn Lab Immunol. 1996 Sep. 3(5):575-7. [QxMD MEDLINE Link]. [Full Text].

68. Gelal F, Kumral E, Vidinli BD, Erdogan D, Yucel K, Erdogan N. Diffusion-weighted and conventional MR imaging in neurotrichinosis. Acta Radiol. 2005 Apr. 46(2):196-9. [QxMD MEDLINE Link].

69. Neghina R, Neghina AM, Marincu I. Reviews on trichinellosis (III): cardiovascular involvement. Foodborne Pathog Dis. 2011 Aug. 8(8):853-60. [QxMD MEDLINE Link].

70. Astudillo LM, Arlet PM. Images in clinical medicine. The chemosis of trichinosis. N Engl J Med. 2004 Jul 29. 351(5):487. [QxMD MEDLINE Link].

71. Watt G, Silachamroon U. Areas of uncertainty in the management of human trichinellosis: a clinical perspective. Expert Rev Anti Infect Ther. 2004 Aug. 2(4):649-52. [QxMD MEDLINE Link].

72. Pozio E, Sacchini D, Sacchi L, Tamburrini A, Alberici F. Failure of mebendazole in the treatment of humans with Trichinella spiralis infection at the stage of encapsulating larvae. Clin Infect Dis. 2001 Feb 15. 32(4):638-42. [QxMD MEDLINE Link].

73. Neghina R, Neghina AM, Marincu I. Trichinellosis in hospitalized patients from a Romanian endemic area, 2007-2009. Clin Microbiol Infect. 2012 Jan. 18(1):86-90. [QxMD MEDLINE Link].

74. Neghina R, Neghina AM, Marincu I. Trichinosis in children and adults.

75. Akkoc N, Kuruuzum Z, Akar S, et al. A large-scale outbreak of trichinellosis caused by Trichinella britovi in Turkey. Zoonoses Public Health. 2009 Mar. 56(2):65-70. [QxMD MEDLINE Link].

76. Caner A, Doskaya M, Degirmenci A, Can H, Baykan S, Uner A, et al. Comparison of the effects of Artemisia vulgaris and Artemisia absinthium growing in western Anatolia against trichinellosis (Trichinella spiralis) in rats. Exp Parasitol. 2008 May. 119(1):173-9. [QxMD MEDLINE Link].

77. Cosoroaba I, Orjanu N. Congenital trichinellosis in the rat. Vet Parasitol. 1998 Jun 15. 77(2-3):147-51. [QxMD MEDLINE Link].

78. Greene YG, Padovani T, Rudroff JA, Hall R, Austin C, Vernon M, et al. Trichinellosis caused by consumption of wild boar meat - Illinois, 2013. MMWR Morb Mortal Wkly Rep. 2014 May 23. 63 (20):451. [QxMD MEDLINE Link]. [Full Text].

L Kristian Arnold, MD, MPH Chief Medical Officer, ArLac Global Health Services, Lexington, MA; Medical Director, Boston Police Department; Assistant Professor (Retired), Emergency Medicine, Boston University School of Medicine

L Kristian Arnold, MD, MPH is a member of the following medical societies: American College of Emergency Physicians, Massachusetts Medical Society, American College of Occupational and Environmental Medicine

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Mark L Plaster, MD, JD Executive Editor, Emergency Physicians Monthly

Mark L Plaster, MD, JD is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians

Disclosure: Received ownership interest from M L Plaster Publishing Co LLC for management position.

Jeter (Jay) Pritchard Taylor, III, MD Assistant Professor, Department of Surgery, University of South Carolina School of Medicine; Attending Physician / Clinical Instructor, Compliance Officer, Department of Emergency Medicine, Prisma Health Richland Hospital

Jeter (Jay) Pritchard Taylor, III, MD is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, Columbia Medical Society, Society for Academic Emergency Medicine, South Carolina College of Emergency Physicians, South Carolina Medical Association

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Employed contractor - Chief Editor for Medscape.

Theodore J Gaeta, DO, MPH, FACEP Clinical Associate Professor, Department of Emergency Medicine, Weill Cornell Medical College; Vice Chairman and Program Director of Emergency Medicine Residency Program, Department of Emergency Medicine, New York Methodist Hospital; Academic Chair, Adjunct Professor, Department of Emergency Medicine, St George's University School of Medicine

Theodore J Gaeta, DO, MPH, FACEP is a member of the following medical societies: American College of Emergency Physicians, New York Academy of Medicine, Society for Academic Emergency Medicine, Council of Residency Directors in Emergency Medicine, Clerkship Directors in Emergency Medicine, Alliance for Clinical Education

Disclosure: Nothing to disclose.

I would like to thank the many primary level researchers from around the globe who helped me improve my understanding through email communications, sharing pdf and hard copies of publications to which I did not have direct access and encouraging me for the value of this "offbeat" Emergency Medicine topic. Thank you, Domo Arigato, Merci Beaucoup, Molto Gracie.

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