Trichuris Trichiura (Whipworm) Infection (Trichuriasis) Medication

Updated: Sep 20, 2018
  • Author: Kwame Donkor, MD; Chief Editor: Jeter (Jay) Pritchard Taylor, III, MD  more...
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Medication Summary

The drug of choice for trichuriasis is mebendazole. A single 500-mg dose can result in a cure rate of 40%-75%. Albendazole is an alternative drug. However, its efficacy for trichuriasis is slightly lower than for mebendazole. [3, 4]

Oxantel pamoate (not currently available in the United States) has shown efficacy in the treatment of trichuriasis. Using oxantel pamoate in combination with either mebendazole or albendazole results in a much higher cure rate than monotherapy.


Anthelmintic agents

Class Summary

Parasite biochemical pathways are sufficiently different from the human host to allow selective interference by chemotherapeutic agents in relatively small doses.

Mebendazole (Emverm)

Causes worm death by selectively and irreversibly blocking glucose uptake and other nutrients in the susceptible adult intestine where helminths dwell. Available as a 100-mg chewable tablet that can be swallowed whole, chewed, or crushed and mixed with food.

Administer a second course if patient is not cured within 3-4 wk.

Albendazole (Albenza)

Decreases whipworm ATP production, causing energy depletion, immobilization, and death.