Pregnancy Trauma Medication

Updated: Dec 03, 2020
  • Author: Andrew K Chang, MD, MS; Chief Editor: Bruce M Lo, MD, MBA, RDMS, FACEP, FAAEM, FACHE, FAAPL, CPE  more...
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Medication Summary

The goal of therapy is to prevent immune response to Rh-negative fetus after trauma. RhoGAM (Rh immunoglobulin G) is administered for this purpose.


Immune serum

Class Summary

Suppresses immune response of nonsensitized Rho(D)–negative mothers who are exposed to Rho(D)–positive blood from the fetus, resulting from a fetomaternal hemorrhage, abdominal trauma, amniocentesis, abortion, full-term delivery, or transfusion accident.

Rho(D) immune globulin (RhoGAM)

Administered if the patient is Rh-negative, unless the father also is Rh-negative. Suppresses the immune response of nonsensitized Rh-negative mothers after delivery of Rh-positive infant. Prevents sensitization to Rho(D) factor. Prevents erythroblastosis fetalis in subsequent pregnancy. When administered near the time of delivery, RhIgG may interfere with Rh typing of the newborn.