Rh Incompatibility Differential Diagnoses

Updated: Mar 15, 2017
  • Author: Leon Salem, MD, MS; Chief Editor: Bruce M Lo, MD, MBA, CPE, RDMS, FACEP, FAAEM, FACHE  more...
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Diagnostic Considerations

Potential reasons for postpartum clinical failures include the following:

  • Failure to type the patient's blood during the ED visit
  • Failure to administer Rh IgG when indicated
  • Error in typing the mother's or infant's blood
  • Unrecognized fetomaternal hemorrhage
  • Inadequate Rh IgG dosage for the volume of fetomaternal hemorrhage

Other conditions to consider in patients with suspected Rh incompatibility include the following:

  • ABO incompatibility
  • Autoimmune hemolytic anemia
  • Microangiopathic hemolytic anemia
  • Spherocytosis
  • Hereditary enzyme deficiencies
  • Alpha thalassemia
  • Chronic fetomaternal hemorrhage
  • Twin-twin transfusion
  • Erythroblastosis fetalis
  • Hydrops fetalis