Rh Incompatibility Differential Diagnoses

Updated: Mar 15, 2017
  • Author: Leon Salem, MD, MS; Chief Editor: Bruce M Lo, MD, MBA, CPE, RDMS, FACEP, FAAEM, FACHE  more...
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DDx

Diagnostic Considerations

Potential reasons for postpartum clinical failures include the following:

  • Failure to type the patient's blood during the ED visit

  • Failure to administer Rh IgG when indicated

  • Error in typing the mother's or infant's blood

  • Unrecognized fetomaternal hemorrhage

  • Inadequate Rh IgG dosage for the volume of fetomaternal hemorrhage

Other conditions to consider in patients with suspected Rh incompatibility include the following:

  • ABO incompatibility

  • Autoimmune hemolytic anemia

  • Microangiopathic hemolytic anemia

  • Spherocytosis

  • Hereditary enzyme deficiencies

  • Alpha thalassemia

  • Chronic fetomaternal hemorrhage

  • Twin-twin transfusion

  • Erythroblastosis fetalis

  • Hydrops fetalis