Neonatal Hypoglycemia Differential Diagnoses

Updated: Apr 07, 2022
  • Author: Hilarie Cranmer, MD, MPH, FACEP; Chief Editor: George T Griffing, MD  more...
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Diagnostic Considerations

Consider the diagnosis of hypoglycemia, especially in a patient with sustained or repetitive episodes of hypoglycemia with resulting seizures and mental retardation. Conditions to consider in the differential diagnosis of hypoglycemia include the following:

  • Fasting

  • Malnutrition

  • Diarrhea

  • Enzymatic defects of glycogen synthetic pathways

  • Enzymatic defects of glycogenolytic pathways

  • Enzymatic defects of gluconeogenic pathways

  • Glucagon deficiency

  • Congenital hyperinsulinism (eg, nesidioblastosis, leucine sensitive hypoglycemia)

  • Defects of beta cell regulation

  • Large tumors

  • Decreased or absent fat stores

  • Enzymatic defects in fatty acid oxidation

Differential Diagnoses