Neonatal Hypoglycemia Differential Diagnoses

Updated: Apr 16, 2017
  • Author: Hilarie Cranmer, MD, MPH, FACEP; Chief Editor: George T Griffing, MD  more...
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Diagnostic Considerations

Consider the diagnosis of hypoglycemia, especially in a patient with sustained or repetitive episodes of hypoglycemia with resulting seizures and mental retardation. Conditions to consider in the differential diagnosis of hypoglycemia include the following:

  • Fasting
  • Malnutrition
  • Diarrhea
  • Enzymatic defects of glycogen synthetic pathways
  • Enzymatic defects of glycogenolytic pathways
  • Enzymatic defects of gluconeogenic pathways
  • Glucagon deficiency
  • Congenital hyperinsulinism (eg, nesidioblastosis, leucine sensitive hypoglycemia)
  • Defects of beta cell regulation
  • Large tumors
  • Decreased or absent fat stores
  • Enzymatic defects in fatty acid oxidation

Differential Diagnoses