Medication
Medication Summary
The goals of pharmacotherapy are to reduce morbidity and prevent complications.
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Antipyretics
Class Summary
These agents may be used to decrease fever.
Acetaminophen (Tylenol)
Reduces fever by direct action on the hypothalamic heat-regulating centers, which increases dissipation of body heat by vasodilation and sweating.
Ibuprofen (Motrin, Advil)
NSAID that inhibits cyclooxygenase, inhibiting formation of prostaglandins.
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Antihistamines
Class Summary
May be used to control itching.
Diphenhydramine (Benadryl)
Competitive antagonist of histamine at the H1 receptor prevents histamine response in sensory nerve endings and blood vessels. More effective in preventing histamine response than reversing it.
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Media Gallery
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Image in a 4-year-old girl with a 4-day history of low-grade fever, symptoms of an upper respiratory tract infection, and rash. Courtesy of Pamela L. Dyne, MD.
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