Pediatric Pyloric Stenosis Medication

Updated: Nov 13, 2018
  • Author: Sathyaseelan Subramaniam, MD, FAAP; Chief Editor: Kirsten A Bechtel, MD  more...
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Medication Summary

See the list below:

  • Atropine has been studied as a potential for conservative management of pyloric stenosis. It is either administered intravenously or orally with the goal of treatment being cessation of projectile vomiting. Success rates vary across studies from 76% to 100% with a mean hospital length of stay of 13 days. [16]
  • The intravenous dose of atropine for treatment of pyloric stenosis ranges in studies from 0.04 to 0.225mg/kg/day and is given for 1 – 10 days.
  • Oral atropine (0.08 – 0.45mg/kg/day) is continued, after IV therapy has been deemed successful, for 3 weeks to 4 months. Predictors of failure are a total of 5 or more projectile vomiting episodes during the first 72 hours of intravenous atropine therapy.
  • Side effects of atropine therapy are rare and include mild facial flushing, raised alanine transaminase and tachycardia. [16]