Tendonitis Medication

Updated: Dec 23, 2016
  • Author: Mark Steele, MD; Chief Editor: Herbert S Diamond, MD  more...
  • Print
Medication

Medication Summary

The goals of pharmacotherapy are to control pain and decrease inflammation. Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in relieving tendinopathy pain, and may be administered topically or orally. Corticosteroids may be considered when conservative therapy has failed.

Next:

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Class Summary

These agents are used for the relief of mild to moderate pain. Although the effects of NSAIDs in the treatment of pain tend to be patient specific, ibuprofen usually is the drug of choice (DOC) for initial therapy. Other options include naproxen and indomethacin.

Ibuprofen (Motrin, Advil, Ibuprin, Nuprin)

Usually DOC for treatment of mild to moderate pain if no contraindications are present.

Inhibits inflammatory reactions and pain, probably by decreasing activity of the enzyme cyclooxygenase, which results in inhibition of prostaglandin synthesis.

Naproxen (Naprosyn, Aleve)

For relief of mild to moderate pain. Inhibits inflammatory reactions and pain by decreasing activity of enzyme cyclooxygenase, which results in decrease of prostaglandin synthesis.

Indomethacin (Indocin, Indochron E-R)

Rapidly absorbed; metabolism occurs in liver by demethylation, deacetylation, and glucuronide conjugation; inhibits prostaglandin synthesis.

Previous
Next:

Corticosteroids

Class Summary

These agents have both anti-inflammatory (glucocorticoid) and salt-retaining (mineralocorticoid) properties. Glucocorticoids have profound and varied metabolic effects. In addition, these agents modify the body's immune response to diverse stimuli.

Dexamethasone acetate (Decadron, AK-Dex, Alba-Dex, Dexone)

Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reducing capillary permeability. Dosage varies with degree of inflammation and size of affected area.

Methylprednisolone acetate (Solu-Medrol, Depo-Medrol, Medrol)

Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing increased capillary permeability.

Use 0.5-1 mL (40 mg/mL) mixed with equal or double volume of 1% local anesthetic (ie, lidocaine). Dosage varies with degree of inflammation and size of affected area.

Hydrocortisone acetate (Solu-Cortef, Cortef)

Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing increased capillary permeability.

Use 0.5-1 mL (25 or 50 mg/mL) mixed with equal or double volume of 1% local anesthetic (ie, lidocaine). Dosage varies with degree of inflammation and size of affected area.

Previous