Antidepressant Toxicity Follow-up

Updated: Apr 12, 2015
  • Author: Jeena Jacob, MD, PharmD; Chief Editor: Asim Tarabar, MD  more...
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Follow-up

Further Inpatient Care

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  • Patients being treated for antidepressant toxicity may need repeat boluses of bicarbonate and may require cardiac monitoring and ICU care if admitted.

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Complications

Complications of antidepressant toxicity may include the following:

  • CNS sequelae

  • Seizures

  • Dysrhythmias

  • Hypotension

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Prognosis

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  • Prognosis is generally favorable without long-term CNS or cardiovascular sequelae in patients who survive initial toxicity. Patients show clinical signs of toxicity in the first 6 hours; survival beyond this time suggests a favorable prognosis unless severe hypoxia or hypotension were present before initial treatment.

  • A small subset may have prolonged neurologic sequelae after status seizures or persistent hypotension.

  • Patients who remain asymptomatic without medical intervention following 6 hours of emergency department observation receive GI decontamination and have normal EKG findings with normal QRS duration may be medically cleared.

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Patient Education

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