Benzodiazepine Toxicity Questions & Answers

Updated: Jun 13, 2018
  • Author: Chip Gresham, MD, FACEM; Chief Editor: Gil Z Shlamovitz, MD, FACEP  more...
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Questions & Answers

Overview

What is the oral benzodiazepine (BZD) toxicity?

What are the signs and symptoms of benzodiazepine (BZD) overdose?

Which physical findings are characteristic of benzodiazepine (BZD) toxicity?

What is the role of immunoassay screening in the workup of benzodiazepine (BZD) toxicity?

Which lab tests are performed in the workup of an intentional benzodiazepine (BZD) overdose?

How is benzodiazepine (BZD) toxicity treated?

What causes benzodiazepine (BZD) toxicity?

What is the pathophysiology of benzodiazepine (BZD) toxicity?

What is the prevalence of benzodiazepine (BZD) toxicity?

What is the mortality and morbidity associated with benzodiazepine (BZD) toxicity?

What is the prognosis of benzodiazepine (BZD) toxicity?

Presentation

Which clinical history findings are characteristic of benzodiazepine (BZD) toxicity?

Which physical findings are characteristic of benzodiazepine (BZD) toxicity?

DDX

What are the differential diagnoses for Benzodiazepine Toxicity?

Workup

Which lab tests are used to detect benzodiazepines (BZDs) in patients with a suspected toxic reaction?

What is included in the workup of benzodiazepine (BZD) toxicity?

Which lab tests are performed in the evaluation of an intentional benzodiazepine (BZD) overdose?

Treatment

How is benzodiazepine (BZD) toxicity treated?

What is included in prehospital care of patients with benzodiazepine (BZD) toxicity?

When is naloxone indicated in the treatment of benzodiazepine (BZD) toxicity?

What is the role of flumazenil in the treatment of benzodiazepine (BZD) toxicity?

Medications

What is the role of activated charcoal in the treatment of benzodiazepine (BZD) toxicity?

Which medications in the drug class Antidotes, Other are used in the treatment of Benzodiazepine Toxicity?