Beta-Blocker Toxicity Questions & Answers

Updated: Jan 18, 2018
  • Author: Adhi Sharma, MD; Chief Editor: Gil Z Shlamovitz, MD, FACEP  more...
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Questions & Answers

Overview

What are the clinical manifestations of beta-blocker toxicity?

Why has the incidence of beta-blocker toxicity been on the increase?

What causes beta-blocker toxicity in children?

What is the mechanism of action associated with beta-blockers?

What is the pathophysiology of beta-receptors in beta-blocker toxicity?

What are mechanisms of beta-blocker toxicity?

Why is understanding the characteristics of different beta-blockers important in the management beta-blocker toxicity?

What are nonselective beta-blockers?

Why is the beta-blocker toxicity of acebutolol particularly lethal in overdose?

What is the role of membrane-stabilizing activity in beta-blocker toxicity?

What is the role of lipid solubility in beta-blocker toxicity?

What are the electrophysiologic effects of sotalol in beta-blocker toxicity?

What is the incidence of beta-blocker toxicity?

What is the prognosis of beta-blocker toxicity?

What are the possible outcomes of beta-blocker toxicity?

Presentation

What should be the focus of history in the evaluation of beta-blocker toxicity?

What are the symptoms of beta-blocker toxicity?

What are the indications of myocardial conduction in beta-blocker toxicity?

What is the effect of beta-blocker toxicity on cardiac output?

How quickly do symptoms of beta-blocker toxicity develop?

What causes and increase in the half-life of beta-blockers during an overdose?

Why are prolonged effects of beta-blocker toxicity common?

What are the indications of asymptomatic beta-blocker toxicity?

Which factors increase the risk of circulatory collapse in beta-blocker toxicity?

What is the significance of a moderate drop in blood pressure in beta-blocker toxicity?

What are the signs of bradycardia in beta-blocker toxicity?

What are the CNS symptoms of beta-blocker toxicity?

How are seizures characterized in beta-blocker toxicity?

How is a coma characterized in beta-blocker toxicity?

What are the symptoms of long-term beta-blocker use in beta-blocker toxicity?

What is the respiratory symptoms of beta-blocker toxicity?

DDX

What are the differential diagnoses for Beta-Blocker Toxicity?

Workup

What is included in the initial workup of beta-blocker toxicity?

What is the role of blood gas in the workup of beta-blocker toxicity?

What is the role of chest radiographs in the workup of beta-blocker toxicity?

Which electrocardiographic (ECG) results suggest beta-blocker toxicity?

Treatment

What is the goal of therapy for beta-blocker toxicity?

When is transfer indicated for the treatment of beta-blocker toxicity?

What is included in prehospital care for beta-blocker toxicity?

When is prehospital administration of charcoal indicated in the treatment of beta-blocker toxicity?

What is the role of ipecac syrup in the treatment of beta-blocker toxicity?

What is included in emergency department (ED) care of beta-blocker toxicity in patients who are hypotensive?

What are the drug treatment options for beta-blocker toxicity in the emergency department (ED)?

What is the role of glucagon in the emergency department (ED) treatment of beta-blocker toxicity?

What is the role of gastric decontamination in the treatment of beta-blocker toxicity?

What is the role of charcoal in the treatment of beta-blocker toxicity?

What is the role of hemodialysis in the treatment of beta-blocker toxicity?

What is the role of cardiac pacing in the treatment of beta-blocker toxicity?

What is the role of cardiac resuscitation in the treatment of beta-blocker toxicity?

What is the role of high-dose insulin in the treatment of beta-blocker toxicity?

What is the optimal regimen for high-dose insulin in the treatment of beta-blocker toxicity?

What are the indications for high-dose insulin in the treatment of beta-blocker toxicity?

What monitoring is required during high-dose insulin therapy for beta-blocker toxicity?

What monitoring is performed during treatment of beta-blocker toxicity?

What are the end points of therapy for beta-blocker toxicity?

What invasive monitoring methods are used during the treatment of severe beta-blocker toxicity?

What is the role of IV fat emulsion (IFE) in the treatment of beta-blocker toxicity?

How is IV fat emulsion (IFE) used to treat beta-blocker toxicity?

What are the adverse effects of IV fat emulsion (IFE) to treat beta-blocker toxicity?

Which specialist consultations are needed for the treatment of beta-blocker toxicity?

How long should patients with beta-blocker toxicity remain asymptomatic before discharge?

What steps are taken to avoid recurrent complications of beta-blocker toxicity?

When is a psychiatric consultation indicated in the treatment of beta-blocker toxicity?

Medications

Which medications are used to the treat beta-blocker toxicity?

Which medications in the drug class Anticonvulsants, Barbiturates are used in the treatment of Beta-Blocker Toxicity?

Which medications in the drug class Benzodiazepines are used in the treatment of Beta-Blocker Toxicity?

Which medications in the drug class Cardiovascular agents are used in the treatment of Beta-Blocker Toxicity?

Which medications in the drug class Gastrointestinal Tract Decontaminants are used in the treatment of Beta-Blocker Toxicity?