Disulfiram Toxicity Workup

Updated: Jan 06, 2016
  • Author: Samara Soghoian, MD, MA; Chief Editor: Asim Tarabar, MD  more...
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Workup

Laboratory Studies

For suspected disulfiram toxicity, the following laboratory studies should be obtained:

  • Glucose level
  • Electrolyte levels
  • Renal function tests
  • Liver function tests
  • Ethanol level
  • Acetaminophen level
  • Arterial blood gas analysis
  • Methemoglobin level (%)
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Imaging Studies

CT of the head and/or MRI studies are valuable in demonstrating CNS involvement (eg, basal ganglia ischemia, infarction) as well as in excluding other causes of altered mental status.

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Other Tests

Specific laboratory studies generally have little value in the treatment of acute toxicity. In addition, results are not usually available in a timely fashion.

Other specific laboratory studies to consider are as follows:

  • Acetaldehyde level test (toxic level >5 mg/L)
  • DDC level test
  • CS 2 level test
  • Tetraethylthiuram level (disulfiram level) test
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Procedures

In patients with hypotension and/or tachycardia, an ECG may assist in the assessment of potential end-organ damage as well as the exclusion of other possible causes of the patient's symptoms. [9]

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