Disulfiram Toxicity Workup

Updated: Nov 01, 2019
  • Author: Samara Soghoian, MD, MA; Chief Editor: Sage W Wiener, MD  more...
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Approach Considerations

Specific laboratory studies generally have little value in the treatment of acute toxicity. In addition, results are not usually available in a timely fashion.


Laboratory Studies

For suspected disulfiram toxicity, the following laboratory studies should be obtained:

  • Glucose level

  • Electrolyte levels

  • Renal function tests

  • Liver function tests

  • Ethanol level

  • Acetaminophen level

  • Arterial blood gas analysis

  • Methemoglobin level (%)

Other specific laboratory studies to consider are as follows:

  • Acetaldehyde level test (toxic level >5 mg/L)

  • DDC level test

  • CS2 level test

  • Tetraethylthiuram level (disulfiram level) test


Imaging Studies

CT of the head and/or MRI studies are valuable in demonstrating CNS involvement (eg, basal ganglia ischemia, infarction) as well as in excluding other causes of altered mental status.



In patients with hypotension and/or tachycardia, an ECG may assist in the assessment of potential end-organ damage as well as the exclusion of other possible causes of the patient's symptoms. [11]