Disulfiram Toxicity Workup

Updated: Jan 06, 2016
  • Author: Samara Soghoian, MD, MA; Chief Editor: Asim Tarabar, MD  more...
  • Print

Laboratory Studies

For suspected disulfiram toxicity, the following laboratory studies should be obtained:

  • Glucose level
  • Electrolyte levels
  • Renal function tests
  • Liver function tests
  • Ethanol level
  • Acetaminophen level
  • Arterial blood gas analysis
  • Methemoglobin level (%)

Imaging Studies

CT of the head and/or MRI studies are valuable in demonstrating CNS involvement (eg, basal ganglia ischemia, infarction) as well as in excluding other causes of altered mental status.


Other Tests

Specific laboratory studies generally have little value in the treatment of acute toxicity. In addition, results are not usually available in a timely fashion.

Other specific laboratory studies to consider are as follows:

  • Acetaldehyde level test (toxic level >5 mg/L)
  • DDC level test
  • CS 2 level test
  • Tetraethylthiuram level (disulfiram level) test


In patients with hypotension and/or tachycardia, an ECG may assist in the assessment of potential end-organ damage as well as the exclusion of other possible causes of the patient's symptoms. [9]