Organochlorine Pesticide Toxicity Differential Diagnoses

1. Bhalla M, Thami GP. Reversible neurotoxicity after an overdose of topical lindane in an infant. Pediatr Dermatol. 2004 Sep-Oct. 21(5):597-9. [QxMD MEDLINE Link].

2. Stockholm Convention. Available at http://chm.pops.int/TheConvention/ThePOPs/The12InitialPOPs/tabid/296/Default.aspx. Accessed: April 9, 2022.

3. Paul Muller Biographical. NobelPrize.org. Available at http://www.nobelprize.org/nobel_prizes/medicine/laureates/1948/muller-bio.html. Accessed: April 9, 2022.

4. DDT - A Brief History and Status. United States Environmental Protection Agency. Available at https://www.epa.gov/ingredients-used-pesticide-products/ddt-brief-history-and-status. Accessed: April 9, 2022.

5. Reigart JR, Roberts JR, eds. Recognition and Management of Pesticide Poisonings. 5th ed. Washington DC: Environmental Protection Agency; 1999.

6. Centers for Disease Control and Prevention. Acute convulsions associated with endrin poisoning--Pakistan. MMWR Morb Mortal Wkly Rep. 1984 Dec 14. 33(49):687-8, 693. [QxMD MEDLINE Link].

7. Centers for Disease Control and Prevention. Unintentional topical lindane ingestions--United States, 1998-2003. MMWR Morb Mortal Wkly Rep. 2005 Jun 3. 54(21):533-5. [QxMD MEDLINE Link].

8. Pramanik AK, Hansen RC. Transcutaneous gamma benzene hexachloride absorption and toxicity in infants and children. Arch Dermatol. 1979 Oct. 115(10):1224-5. [QxMD MEDLINE Link].

9. Mortensen ML. Management of acute childhood poisonings caused by selected insecticides and herbicides. Pediatr Clin North Am. 1986 Apr. 33(2):421-45. [QxMD MEDLINE Link].

10. Karatas AD, Aygun D, Baydin A. Characteristics of endosulfan poisoning: a study of 23 cases. Singapore Med J. 2006 Dec. 47(12):1030-2. [QxMD MEDLINE Link].

11. Roberts DM, Dissanayake W, Rezvi Sheriff MH, Eddleston M. Refractory status epilepticus following self-poisoning with the organochlorine pesticide endosulfan. J Clin Neurosci. 2004 Sep. 11(7):760-2. [QxMD MEDLINE Link].

12. Kanthasamy AG, Kitazawa M, Kaul S, Yang Y, Lahiri DK, Anantharam V. Proteolytic activation of proapoptotic kinase PKCdelta is regulated by overexpression of Bcl-2: implications for oxidative stress and environmental factors in Parkinson's disease. Ann N Y Acad Sci. 2003 Dec. 1010:683-6. [QxMD MEDLINE Link].

13. Kintz P, Baron L, Tracqui A, Peton P, Coudane H, Mangin P. A high endrin concentration in a fatal case. Forensic Sci Int. 1992 May. 54(2):177-80. [QxMD MEDLINE Link].

14. van der Hoek W, Konradsen F. Risk factors for acute pesticide poisoning in Sri Lanka. Trop Med Int Health. 2005 Jun. 10(6):589-96. [QxMD MEDLINE Link].

15. Wilson WW, Shapiro LP, Bradner JM, Caudle WM. Developmental exposure to the organochlorine insecticide endosulfan damages the nigrostriatal dopamine system in male offspring. Neurotoxicology. 2014 Sep. 44:279-87. [QxMD MEDLINE Link].

16. Gummin DD, Mowry JB, Beuhler MC, Spyker DA, Bronstein AC, Rivers LJ, et al. 2020 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 38th Annual Report. Clin Toxicol (Phila). 2021 Dec. 59 (12):1282-1501. [QxMD MEDLINE Link]. [Full Text].

17. Moon JM, Chun BJ. Acute endosulfan poisoning: a retrospective study. Hum Exp Toxicol. 2009 May. 28(5):309-16. [QxMD MEDLINE Link].

18. Srinivas Rao Ch, Venkateswarlu V, Surender T, Eddleston M, Buckley NA. Pesticide poisoning in south India: opportunities for prevention and improved medical management. Trop Med Int Health. 2005 Jun. 10(6):581-8. [QxMD MEDLINE Link]. [Full Text].

19. Freire C, Koifman RJ, Koifman S. Hematological and hepatic alterations in Brazilian population heavily exposed to organochlorine pesticides. J Toxicol Environ Health A. 2015. 78 (8):534-48. [QxMD MEDLINE Link].

20. VoPham T, Bertrand KA, Hart JE, Laden F, Brooks MM, Yuan JM, et al. Pesticide exposure and liver cancer: a review. Cancer Causes Control. 2017 Mar. 28 (3):177-190. [QxMD MEDLINE Link]. [Full Text].

21. Koutros S, Silverman DT, Alavanja MC, Andreotti G, Lerro CC, Heltshe S, et al. Occupational exposure to pesticides and bladder cancer risk. Int J Epidemiol. 2016 Jun. 45 (3):792-805. [QxMD MEDLINE Link]. [Full Text].

22. Lee YM, Ha CM, Kim SA, Thoudam T, Yoon YR, Kim DJ, et al. Low-Dose Persistent Organic Pollutants Impair Insulin Secretory Function of Pancreatic β-Cells: Human and In Vitro Evidence. Diabetes. 2017 Oct. 66 (10):2669-2680. [QxMD MEDLINE Link]. [Full Text].

23. Su FC, Goutman SA, Chernyak S, Mukherjee B, Callaghan BC, Batterman S, et al. Association of Environmental Toxins With Amyotrophic Lateral Sclerosis. JAMA Neurol. 2016 Jul 1. 73 (7):803-11. [QxMD MEDLINE Link]. [Full Text].

24. Nandipati S, Litvan I. Environmental Exposures and Parkinson's Disease. Int J Environ Res Public Health. 2016 Sep 3. 13 (9):[QxMD MEDLINE Link]. [Full Text].

25. Fry K, Power MC. Persistent organic pollutants and mortality in the United States, NHANES 1999-2011. Environ Health. 2017 Oct 10. 16 (1):105. [QxMD MEDLINE Link]. [Full Text].

26. Polanco Rodríguez ÁG, Inmaculada Riba López M, Angel DelValls Casillas T, León JA, Anjan Kumar Prusty B, Álvarez Cervera FJ. Levels of persistent organic pollutants in breast milk of Maya women in Yucatan, Mexico. Environ Monit Assess. 2017 Feb. 189 (2):59. [QxMD MEDLINE Link].

27. Dally S, Garnier R, Bismuth C. Diagnosis of chlorinated hydrocarbon poisoning by x ray examination. Br J Ind Med. 1987 Jun. 44(6):424-5. [QxMD MEDLINE Link].

28. Morgan DP, Dotson TB, Lin LI. Effectiveness of activated charcoal, mineral oil, and castor oil in limiting gastrointestinal absorption of a chlorinated hydrocarbon pesticide. Clin Toxicol. 1977. 11(1):61-70. [QxMD MEDLINE Link].

29. Kassner JT, Maher TJ, Hull KM, Woolf AD. Cholestyramine as an adsorbent in acute lindane poisoning: a murine model. Ann Emerg Med. 1993 Sep. 22(9):1392-7. [QxMD MEDLINE Link].

30. Cohn WJ, Boylan JJ, Blanke RV, Fariss MW, Howell JR, Guzelian PS. Treatment of chlordecone (Kepone) toxicity with cholestyramine. Results of a controlled clinical trial. N Engl J Med. 1978 Feb 2. 298(5):243-8. [QxMD MEDLINE Link].

31. Mutter LC, Blanke RV, Jandacek RJ, Guzelian PS. Reduction in the body content of DDE in the Mongolian gerbil treated with sucrose polyester and caloric restriction. Toxicol Appl Pharmacol. 1988 Mar 15. 92(3):428-35. [QxMD MEDLINE Link].

32. Moses V, Peter JV. Acute intentional toxicity: endosulfan and other organochlorines. Clin Toxicol (Phila). 2010 Jul. 48(6):539-44. [QxMD MEDLINE Link].

Matthew L Wong, MD, MPH Resident Physician, Harvard Affiliated Emergency Medicine Residency Program, Department of Emergency Medicine, Beth Israel Deaconess Medical Center

Disclosure: Nothing to disclose.

Jennifer Vyse Pope, MD Staff Physician, Department of Emergency Medicine, Beth Israel Deaconess Medical Center

Jennifer Vyse Pope, MD is a member of the following medical societies: Phi Beta Kappa

Disclosure: Nothing to disclose.

Carlo L Rosen, MD Associate Professor of Medicine, Harvard Medical School; Associate Director of Graduate Medical Education, Harvard Affiliated Emergency Medicine Residency Program, Executive Vice Chair, Department of Emergency Medicine, Beth Israel Deaconess Medical Center

Carlo L Rosen, MD is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Michael A Miller, MD Clinical Professor of Emergency Medicine, Medical Toxicologist, Department of Emergency Medicine, Texas A&M Health Sciences Center; CHRISTUS Spohn Emergency Medicine Residency Program

Michael A Miller, MD is a member of the following medical societies: American College of Medical Toxicology

Disclosure: Nothing to disclose.

Morgan Skurky-Thomas, MD Resident Physician, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School

Morgan Skurky-Thomas, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Emergency Physicians, American Medical Association, and Phi Beta Kappa

Disclosure: Nothing to disclose.

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