Opioid Toxicity Questions & Answers

Updated: Jun 06, 2020
  • Author: Everett Stephens, MD; Chief Editor: Jeter (Jay) Pritchard Taylor, III, MD  more...
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Questions & Answers

Overview

What is fentanyl?

What are the mortality rates for opioid toxicity?

When should opioid toxicity be suspected?

What is opioid toxicity?

What is the pathophysiology of opioid toxicity?

What is the prevalence of opioid toxicity in the US?

What is the global prevalence of opioid toxicity?

What is the morbidity associated with opioid toxicity?

What is the role of naloxone (Evzio) in the treatment of opioid toxicity?

Presentation

Which clinical history findings are characteristic of opioid toxicity?

Which physical findings are characteristic of opioid toxicity?

DDX

When should co-ingestants be considered in the differential diagnoses of opioid toxicity?

How does the delivery route affect opioid toxicity?

Which opioid derivatives should be included in the differential diagnoses of opioid toxicity?

What are the differential diagnoses for Opioid Toxicity?

Workup

What is the role of lab tests in the workup of opioid toxicity?

What is the role of imaging studies in the workup of opioid toxicity?

What is the roe of ECG in the diagnosis of opioid toxicity?

Treatment

What is included in prehospital care for opioid toxicity?

What is included in emergency department care for opioid toxicity?

What is the role of activated charcoal in the treatment of opioid toxicity?

What is the role of whole-body irrigation in the treatment of opioid toxicity?

What are the signs and symptoms of hypoxia in opioid toxicity?

What is the role of naloxone in the treatment of pediatric opioid toxicity?

What is the role of buprenorphine/naloxone in the treatment of opioid toxicity combined with another narcotic?

How is narcotic bowel syndrome managed in opioid toxicity?

What is the prevalence of methadone opioid toxicity?

When is inpatient treatment of opioid toxicity indicated?

How is acute lung injury (ALI) treated in opioid toxicity?

What are the possible complications of opioid toxicity in IV drug users?

What are possible complications of opioid toxicity?

How are withdrawal symptoms managed during opioid toxicity treatment?

What are the possible complications of opioid toxicity with adulterants, contaminants, and diluents?

What is the role of naltrexone in the treatment of opioid toxicity?

How is opioid toxicity prevented?

What is the role of naloxone in the outpatient treatment of opioid toxicity?

Medications

What is the role of medications in the treatment of opioid toxicity?

Which medications in the drug class Opioid Reversal Agents are used in the treatment of Opioid Toxicity?