Neuroleptic Malignant Syndrome Questions & Answers

Updated: Dec 23, 2017
  • Author: Theodore I Benzer, MD, PhD; Chief Editor: Gil Z Shlamovitz, MD, FACEP  more...
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Questions & Answers

Overview

What is neuroleptic malignant syndrome (NMS)?

What are the signs and symptoms of neuroleptic malignant syndrome (NMS)?

What are the clinical features of neuroleptic malignant syndrome (NMS)?

Which physical findings indicate autonomic dysregulation in neuroleptic malignant syndrome (NMS)?

Which lab abnormalities suggest neuroleptic malignant syndrome (NMS)?

What are the treatment options for neuroleptic malignant syndrome (NMS)?

What is neuroleptic malignant syndrome (NMS)?

What is the role of atypical antipsychotic drugs in the etiology of neuroleptic malignant syndrome (NMS)?

What precipitates the onset of neuroleptic malignant syndrome (NMS)?

What is the pathophysiology of neuroleptic malignant syndrome (NMS)?

Which medications causes neuroleptic malignant syndrome (NMS)?

What are the risk factors for neuroleptic malignant syndrome (NMS)?

Which factors increase the risk of recurrence for neuroleptic malignant syndrome (NMS)?

What is the prevalence of neuroleptic malignant syndrome (NMS) in the US?

What is the global prevalence of neuroleptic malignant syndrome (NMS)?

Which patient groups are at higher risk for developing neuroleptic malignant syndrome (NMS)?

What is the prognosis of neuroleptic malignant syndrome (NMS)?

What are the complications of neuroleptic malignant syndrome (NMS)?

What is the mortality rate for neuroleptic malignant syndrome (NMS)?

What are the sequelae of neuroleptic malignant syndrome (NMS)?

What is included in patient education about neuroleptic malignant syndrome (NMS)?

Presentation

What are the cardinal clinical features of neuroleptic malignant syndrome (NMS)?

When does neuroleptic malignant syndrome (NMS) occur?

What are the signs and symptoms of neuroleptic malignant syndrome (NMS)?

What is the role of antipsychotic drugs in the development of neuroleptic malignant syndrome (NMS)?

What is the progression of neuroleptic malignant syndrome (NMS)?

What are the physical findings characteristic of neuroleptic malignant syndrome (NMS)?

How is delirium characterized in neuroleptic malignant syndrome (NMS)?

DDX

How is neuroleptic malignant syndrome (NMS) diagnosed?

How is neuroleptic malignant syndrome (NMS) caused by dopamine agonists treated?

Which neurologic conditions should be included in the differential diagnoses of neuroleptic malignant syndrome (NMS)?

How is lethal catatonia (LC) differentiated from neuroleptic malignant syndrome (NMS)?

How is serotonin syndrome differentiated from neuroleptic malignant syndrome (NMS)?

How is malignant hyperthermia differentiated from neuroleptic malignant syndrome (NMS)?

Which general medical conditions should be included in the differential diagnoses of neuroleptic malignant syndrome (NMS)?

What are the differential diagnoses for Neuroleptic Malignant Syndrome?

Workup

Which lab studies are performed in the evaluation of neuroleptic malignant syndrome (NMS)?

Which lab findings suggest neuroleptic malignant syndrome (NMS)?

How are the rigidity and hyperthermia of neuroleptic malignant syndrome (NMS) reflected in lab findings?

How do muscle damage and necrosis in neuroleptic malignant syndrome (NMS) progress?

What lab abnormalities are characteristic of neuroleptic malignant syndrome (NMS)?

When are coagulation studies indicated in the workup of neuroleptic malignant syndrome (NMS)?

What is the role of imaging studies in the diagnosis of neuroleptic malignant syndrome (NMS)?

Treatment

What are the treatment options for neuroleptic malignant syndrome (NMS)?

What is the prehospital care for neuroleptic malignant syndrome (NMS)?

What is included in the treatment of neuroleptic malignant syndrome (NMS)?

How is temperature reduced in the treatment of neuroleptic malignant syndrome (NMS)?

What is the role of electroconvulsive therapy (ECT) in the treatment of neuroleptic malignant syndrome (NMS)?

What is the role of pharmacologic therapy in the treatment of neuroleptic malignant syndrome (NMS)?

How is neuroleptic malignant syndrome (NMS) prevented?

Which specialist consultations are beneficial in the treatment of neuroleptic malignant syndrome (NMS)?

What is included in the long-term monitoring of patients with neuroleptic malignant syndrome (NMS)?

Medications

What is the role of medications in the treatment of neuroleptic malignant syndrome (NMS)?

Which medications in the drug class Dopamine Agonists are used in the treatment of Neuroleptic Malignant Syndrome?

Which medications in the drug class Benzodiazepine-Antispasmodic Agents are used in the treatment of Neuroleptic Malignant Syndrome?

Which medications in the drug class Skeletal Muscle Relaxants are used in the treatment of Neuroleptic Malignant Syndrome?