Nonsteroidal Anti-inflammatory Drug (NSAID) Toxicity Medication

Updated: Dec 20, 2017
  • Author: Timothy J Wiegand, MD; Chief Editor: Gil Z Shlamovitz, MD, FACEP  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity, prevent complications, and reduce the toxic levels of drug. No specific antidotes for nonsteroidal anti-inflammatory drug (NSAID) poisoning exist.

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GI decontaminant

Class Summary

These agents may bind and limit absorption of NSAIDs from the GI tract.

Activated charcoal (Liqui-Char)

Emergency treatment in poisoning caused by drugs and chemicals. Network of pores present in activated charcoal adsorbs 100-1000 mg of drug per gram of charcoal. Does not dissolve in water.

For maximum effect, administer within 30 min of ingesting poison. Risk/benefit assessment may be favorable for AC up to 4 hours after exposure. Consult with poison control center.

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Alkalinizing agents

Class Summary

These agents are used to accelerate excretion of the drug.

Sodium bicarbonate (Neut)

Sodium bicarbonate is indicated for the treatment of recalcitrant acidosis (pH < 7).

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