Nonsteroidal Anti-inflammatory Drug (NSAID) Toxicity Medication

Updated: Oct 21, 2021
  • Author: Timothy J Wiegand, MD; Chief Editor: Gil Z Shlamovitz, MD, FACEP  more...
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Medication Summary

The goals of pharmacotherapy are to reduce morbidity, prevent complications, and reduce the toxic levels of drug. No specific antidotes for nonsteroidal anti-inflammatory drug (NSAID) poisoning exist.


GI decontaminant

Class Summary

These agents may bind and limit absorption of NSAIDs from the GI tract.

Activated charcoal (Liqui-Char)

Emergency treatment in poisoning caused by drugs and chemicals. Network of pores present in activated charcoal adsorbs 100-1000 mg of drug per gram of charcoal. Does not dissolve in water.

For maximum effect, administer within 30 min of ingesting poison. Risk/benefit assessment may be favorable for AC up to 4 hours after exposure. Consult with poison control center.


Alkalinizing agents

Class Summary

These agents are used to accelerate excretion of the drug.

Sodium bicarbonate (Neut)

Sodium bicarbonate is indicated for the treatment of recalcitrant acidosis (pH < 7).