Phenytoin Toxicity Questions & Answers

Updated: Dec 31, 2020
  • Author: Charlene Miller, MD; Chief Editor: David Vearrier, MD, MPH  more...
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Questions & Answers

Overview

What is phenytoin toxicity?

What is the pathophysiology of phenytoin toxicity?

What are the pharmacokinetics of phenytoin toxicity?

What is the prevalence of phenytoin toxicity in the US?

What are the sexual predilections of phenytoin toxicity?

Which age groups have the highest prevalence of phenytoin toxicity?

What is the mortality and morbidity associated with phenytoin toxicity?

Presentation

Which clinical history findings are characteristic of acute phenytoin toxicity?

Which clinical history findings are characteristic of chronic phenytoin toxicity?

What is the focus of clinical history to evaluate phenytoin toxicity?

What is the most common adverse effect of phenytoin toxicity?

Which neurological findings suggest phenytoin toxicity?

Which eye exam findings suggest phenytoin toxicity?

What are the signs and symptoms of hypersensitivity reactions to phenytoin toxicity?

Which cardiovascular findings suggest phenytoin toxicity?

Which skin findings suggest phenytoin toxicity?

Which GI findings suggest phenytoin toxicity?

Which physical findings are characteristic of intrauterine exposure to phenytoin?

DDX

How do drug interactions affect phenytoin toxicity?

Serum levels of which medications are increased by phenytoin?

Serum levels of which medications are decreased by phenytoin?

Which medications increase serum levels of phenytoin?

Which medications decrease serum levels of phenytoin?

What are the differential diagnoses for Phenytoin Toxicity?

Workup

What is the role of lab testing in the workup of phenytoin toxicity?

Which lab tests are performed in the workup of acute phenytoin toxicity?

Which lab tests are performed in the workup of hypersensitivity reaction in phenytoin toxicity?

What is the role of imaging studies in the workup of phenytoin toxicity?

What is the role of electrocardiography in the workup of phenytoin toxicity?

Treatment

What is included in prehospital care for phenytoin toxicity?

How is phenytoin toxicity treated?

When is inpatient care indicated in the treatment of phenytoin toxicity?

What is included in the long-term monitoring of phenytoin toxicity?

Which specialist consultations are beneficial to patients with phenytoin toxicity?

Medications

What is the role of medications in the treatment of phenytoin toxicity?

Which medications in the drug class Benzodiazepines are used in the treatment of Phenytoin Toxicity?

Which medications in the drug class GI decontaminant are used in the treatment of Phenytoin Toxicity?