Shellfish Toxicity Workup

Updated: Dec 28, 2015
  • Author: Thomas C Arnold, MD, FAAEM, FACMT; Chief Editor: Asim Tarabar, MD  more...
  • Print
Workup

Laboratory Studies

See the list below:

  • Direct human serum assays for shellfish toxins are not yet available to clinicians. Research in this area is ongoing, and a reliable assay for several of these specific toxins should be available soon.
  • Saxitoxin can be assayed by using a mouse bioassay, ELISA, and high-performance liquid chromatography (HPLC). Brevetoxin can be assayed by using a mouse bioassay, ELISA, and antibody radioimmunoassay (RIA). Liquid chromatography, mass spectrometry, and ELISA techniques have been developed for domoic acid. [7]
  • A new assay was used to quantify saxitoxin and neosaxitoxin in human urine samples, with results suggesting that few false-positive outcomes would occur when attempting to identify people exposed to these toxins. [8]