Vitamin Toxicity Questions & Answers

Updated: Dec 26, 2017
  • Author: Mark Rosenbloom, MD, MBA; Chief Editor: Michael A Miller, MD  more...
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Questions & Answers

Overview

How prevalent is vitamin toxicity in the US?

What causes vitamin toxicity?

What causes vitamin A toxicity?

What are the recommended dietary allowances (RDAs) for vitamin A?

What are the recommended dietary allowances (RDAs) for vitamin A in children?

What is the recommended dietary allowance (RDA) for vitamin B-1?

What is the recommended dietary allowance (RDA) for vitamin B-2 (riboflavin)?

What is the recommended dietary allowance (RDA) for vitamin B-3 (niacin)?

What are the therapeutic uses of vitamin B-6 (pyridoxine)?

What are the recommended dietary allowances (RDAs) for vitamin B-6?

What are the recommended dietary allowances (RDAs) for vitamin B-6 in children?

What are the recommended dietary allowances (RDAs) for vitamin E in children?

What are the recommended dietary allowances (RDAs) for vitamin B-12 (cyanocobalamin)?

What are the recommended dietary allowances (RDAs) for vitamin C (ascorbic acid)?

What are the recommended dietary allowances (RDAs) for vitamin C in children?

What are the recommended dietary allowances (RDAs) for vitamin D (cholecalciferol)?

What causes vitamin E toxicity?

What are the recommended dietary allowances (RDAs) for vitamin E?

What are the recommendations for daily intake of vitamin K?

What is adequate intake of vitamin K in children?

What are the recommended dietary allowances (RDAs) for folic acid?

What are the recommended dietary allowances (RDAs) for folic acid in children?

What is the pathophysiology and of vitamin A toxicity?

What causes vitamin B-1 (thiamine) and vitamin B-2 (riboflavin) toxicity?

At what dosage is vitamin B-3 toxic?

At what dosage is vitamin B-6 toxic?

At what dose is vitamin B-12 toxic?

At what dose is vitamin D toxic?

What is the pathophysiology of vitamin E toxicity?

What are the adverse effects of vitamin E toxicity?

What conditions are complicated by high doses of vitamin E?

What is the toxic dose for vitamin K?

What is the toxic dose for folic acid?

What is the prevalence of vitamin toxicity in the US?

How does the prevalence of vitamin toxicity vary by age?

What is the prognosis of vitamin toxicity?

What is the morbidity and mortality associated with vitamin toxicity?

What information about vitamin toxicity should patients receive?

Presentation

What are the nonspecific signs and symptoms of vitamin toxicity?

What are the signs and symptoms of acute vitamin A toxicity?

What are the signs and symptoms of chronic vitamin A toxicity?

What are the signs and symptoms of carotenemia in vitamin toxicity?

What are the signs and symptoms of vitamin C toxicity?

What are the signs and symptoms of vitamin D toxicity?

What are the signs and symptoms of chronic vitamin D toxicity?

Which clinical history findings are characteristic of vitamin E toxicity?

What are the signs and symptoms of acute vitamin E toxicity?

What are the signs and symptoms of vitamin K toxicity?

Which physical findings are characteristic of acute vitamin A toxicity?

Which physical findings are characteristic of chronic vitamin A toxicity?

What are the effects of vitamin B toxicity?

Which physical findings are characteristic of vitamin B-1 (ie, thiamine) toxicity?

Which physical findings are characteristic of vitamin B-2 (ie, riboflavin) toxicity?

Which physical findings are characteristic of acute vitamin B-3 (ie, niacin, nicotinic acid) toxicity?

Which physical findings are characteristic of chronic vitamin B-3 (ie, niacin, nicotinic acid) toxicity?

Which physical findings are characteristic of vitamin B-6 (ie, pyridoxine) toxicity?

Which physical findings are characteristic of vitamin E toxicity?

DDX

What should be included in the differential diagnoses of vitamin toxicity?

How are the effects of warfarin differentiated from vitamin E toxicity?

What causes of carotenemia should be included in the differential diagnosis of vitamin A toxicity?

What are the differential diagnoses for Vitamin Toxicity?

Workup

What tests are performed in the workup of vitamin toxicity?

What is the role of imaging studies in the diagnosis for vitamin toxicity?

What is the role of electrocardiography in the diagnosis for vitamin toxicity?

What is the toxic level of vitamin A?

What is the role of lab studies in the diagnosis for vitamin A toxicity?

What is the role of high-performance liquid chromatography (HPLC) in the workup of vitamin toxicity?

Which lab studies are used in the diagnosis of vitamin B-1, B-2, and B-12 toxicity?

Which lab studies are used in the diagnosis of vitamin B-3 toxicity?

What is the role of lumbar puncture in the diagnosis of vitamin B-6 toxicity?

Which lab studies are used in the diagnosis of vitamin C toxicity?

Which lab studies are used in the diagnosis of vitamin D toxicity?

Which lab studies are used in the diagnosis of vitamin E toxicity?

Which lab studies are used in the diagnosis of vitamin K toxicity?

Treatment

What is included in emergency department (ED) care for vitamin toxicity?

Which specialist consultations are needed for patients with vitamin toxicity?

What are the treatment options for vitamin A toxicity?

How is vitamin A toxicity treated in patients with symptomatic hypercalcemia?

What are the treatment options for vitamin D toxicity?

How are vitamin K, B-1, B-2, B-6, B-12, and C, and folate toxicity managed?

How is vitamin B-3 toxicity treated?

How is vitamin E toxicity treated?

When is inpatient care indicated in the treatment of vitamin toxicity?

What is included in inpatient care for the treatment of vitamin E toxicity?

Medications

Which medications are used in the treatment of vitamin toxicity?

Which medications in the drug class Calcium Metabolism Modifiers are used in the treatment of Vitamin Toxicity?

Which medications in the drug class Corticosteroids are used in the treatment of Vitamin Toxicity?

Which medications in the drug class Diuretics, Loop are used in the treatment of Vitamin Toxicity?

Which medications in the drug class Antidotes, Other are used in the treatment of Vitamin Toxicity?

Which medications in the drug class Vitamins, Fat-soluble are used in the treatment of Vitamin Toxicity?