Thyroid Hormone Toxicity Clinical Presentation

Updated: Oct 12, 2016
  • Author: Lisandro Irizarry, MD, MPH, FACEP; Chief Editor: Asim Tarabar, MD  more...
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Presentation

History

Access to thyroid hormone, especially in pediatric or unknown ingestions, is important.

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Physical

Focus the physical examination on findings consistent with symptoms of increased adrenergic activity and on the following signs:

  • Acute

    • Abdominal pain

    • Nausea or vomiting

    • Diarrhea

    • Increased appetite

    • Insomnia

    • Anxiousness

    • Agitation

    • Tremor

    • Seizures

    • Weakness

    • Diaphoresis

    • Tachycardia

    • Palpitations

    • Hypertension or hypotension

    • Hyperpyrexia/heat intolerance

    • Confusion

    • Psychosis

    • Hypoglycemia

    • Skin flushing

    • Transient systolic ejection murmurs

    • Pulmonary edema

    • Adrenal insufficiency

  • Chronic

    • Weight loss

    • Menstrual irregularities

    • Supraventricular tachycardia (SVT)

    • High-output left ventricular failure

    • Hypotension

    • Hemiparesis

    • Delirium

    • Coma

    • Pneumonia

    • Sepsis

    • Hyperthermia

    • Acute renal failure

    • Myopathy

    • Palmar and plantar desquamation

    • Premature epiphyseal closure in children

    • Craniosynostosis (infants)

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Causes

Long-term abuse of thyroid supplements has been reported in obese patients as a method of weight control.

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