Thyroid Hormone Toxicity Clinical Presentation

Updated: Oct 12, 2016
  • Author: Lisandro Irizarry, MD, MPH, FACEP; Chief Editor: Asim Tarabar, MD  more...
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Presentation

History

Access to thyroid hormone, especially in pediatric or unknown ingestions, is important.

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Physical

Focus the physical examination on findings consistent with symptoms of increased adrenergic activity and on the following signs:

  • Acute
    • Abdominal pain
    • Nausea or vomiting
    • Diarrhea
    • Increased appetite
    • Insomnia
    • Anxiousness
    • Agitation
    • Tremor
    • Seizures
    • Weakness
    • Diaphoresis
    • Tachycardia
    • Palpitations
    • Hypertension or hypotension
    • Hyperpyrexia/heat intolerance
    • Confusion
    • Psychosis
    • Hypoglycemia
    • Skin flushing
    • Transient systolic ejection murmurs
    • Pulmonary edema
    • Adrenal insufficiency
  • Chronic
    • Weight loss
    • Menstrual irregularities
    • Supraventricular tachycardia (SVT)
    • High-output left ventricular failure
    • Hypotension
    • Hemiparesis
    • Delirium
    • Coma
    • Pneumonia
    • Sepsis
    • Hyperthermia
    • Acute renal failure
    • Myopathy
    • Palmar and plantar desquamation
    • Premature epiphyseal closure in children
    • Craniosynostosis (infants)
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Causes

Long-term abuse of thyroid supplements has been reported in obese patients as a method of weight control.

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