Clonidine Toxicity Medication

Updated: Aug 21, 2023
  • Author: David Riley, MD, MSc, RDMS, RDCS, RVT, RMSK; Chief Editor: Michael A Miller, MD  more...
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Cardiovascular Agents

Dopamine (Intropin)

DOC in patients with clonidine toxicity who remain hypotensive after IVF. Stimulates adrenergic and dopaminergic receptors. Hemodynamic effect is dependent on dose. Lower doses predominantly stimulate dopaminergic receptors that, in turn, produce renal and mesenteric vasodilation. Higher doses produce cardiac stimulation and renal vasodilation.

Atropine IV/IM (Atropair)

Vagolytic for patients with bradycardia (eg, SA or AV nodal block).

Doses < 0.5 mg can produce a paradoxical reaction.



Naloxone (Narcan)

Absolute benefits are unproven and rates of success vary. Consider a drip if significant improvement results.


GI Decontaminant

Activated charcoal (Liqui-Char)

Emergency treatment in poisoning caused by drugs and chemicals. Network of pores present in activated charcoal adsorbs 100-1000 mg of drug per gram of charcoal. Does not dissolve in water.

For maximum effect, administer within 30 min of ingesting poison.