Gamma-Hydroxybutyrate Toxicity Medication

Updated: Oct 11, 2019
  • Author: Theodore I Benzer, MD, PhD; Chief Editor: Sage W Wiener, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.

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GI decontaminant

Class Summary

Prevents further absorption of adsorbable toxins from the GI tract if administered soon after ingestion (typically < 1 h).

Activated charcoal (Liqui-Char)

Emergency treatment in poisoning caused by drugs and chemicals. Network of pores present in activated charcoal adsorbs 100-1000 mg of drug per gram of charcoal. Does not dissolve in water.

For maximum effect, administer within 30 min of ingesting poison. Administer cathartic (sorbitol) with first dose.

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Cardiovascular agents

Class Summary

Bradycardia may be encountered in GHB overdose. Atropine, as an anticholinergic agent, may be useful for treatment of bradycardia.

Atropine IV/IM (Atropair)

Enhances sinus node automaticity by blocking effects of acetylcholine at the AV node, decreasing refractory time and speeding conduction through the AV node.

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