Warfarin and Superwarfarin Toxicity Differential Diagnoses

Updated: Nov 03, 2023
  • Author: Derrick Lung, MD, MPH, FACEP, FACMT; Chief Editor: David Vearrier, MD, MPH  more...
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Diagnostic Considerations

Conditions to consider in the differential diagnosis of warfarin or superwarfarin toxicity include the following:

  • Hemophilia A
  • Hemophilia B
  • Munchausen syndrome
  • Munchausen syndrome by proxy
  • Child abuse
  • Epistaxis
  • GastrointestinaI bleeding
  • Ectopic pregnancy
  • Postpartum hemorrhage
  • Hemorrhagic shock
  • Hypovolemic shock
  • Hemorrhagic stroke
  • Subarachnoid hemorrhage
  • Subdural hematoma
  • Vitreous hemorrhage
  • Liver failure
  • Factor X deficiency
  • Factor V deficiency
  • Afibrinogenemia
  • Dysfibrinogenemia
  • Vitamin K deficiency
  • Malabsorptive states
  • Domestic violence
  • Retroperitoneal hemorrhage

A prolonged prothrombin time (PT) and partial thromboplastin time (PTT) followed by demonstration of specific deficiency of vitamin K–dependent blood coagulation protein activities narrows the diagnostic possibilities. [17]

Differential Diagnoses