Warfarin and Superwarfarin Toxicity Questions & Answers

Updated: Jan 19, 2018
  • Author: Kent R Olson, MD, FACEP; Chief Editor: David Vearrier, MD, MPH  more...
  • Print
Questions & Answers

Overview

What is warfarin and superwarfarin toxicity?

What causes warfarin and superwarfarin toxicity?

Which medications increase the risk for warfarin and superwarfarin toxicity by prolonging prothrombin time (PT)?

What is the role of antibiotics in the pathogenesis of warfarin and superwarfarin toxicity?

Which medications increase the risk for warfarin and superwarfarin toxicity due to an additive anticoagulant effect?

Which medications interfere with protein binding and increase the risk for warfarin and superwarfarin toxicity?

What drugs can cause inhibition of warfarin absorption?

What drugs can cause enhanced warfarin metabolism?

Which foods may increase the risk for warfarin and superwarfarin toxicity?

Which foods are less likely to trigger warfarin and superwarfarin toxicity?

What is the prevalence of warfarin and superwarfarin toxicity in the US?

How does the incidence of warfarin and superwarfarin toxicity vary by age?

What are the complications of hemorrhage caused by warfarin and superwarfarin toxicity?

What causes skin necrosis in warfarin and superwarfarin toxicity?

What are the effects of warfarin and superwarfarin toxicity during pregnancy?

What are the possible adverse reactions to chronic warfarin therapy?

What should be included in patient education about warfarin and superwarfarin toxicity?

Presentation

Which clinical history findings are characteristic of warfarin and superwarfarin toxicity?

Which physical findings are characteristic of warfarin and superwarfarin toxicity?

DDX

Which conditions should be considered in the differential diagnoses of warfarin and superwarfarin toxicity?

What are the differential diagnoses for Warfarin and Superwarfarin Toxicity?

Workup

What is the role of lab studies in the diagnosis of warfarin and superwarfarin toxicity?

Treatment

How is warfarin and superwarfarin toxicity treated?

What is included in prehospital care for warfarin and superwarfarin toxicity?

What is the initial treatment for warfarin and superwarfarin toxicity in the emergency department (ED)?

How is acute warfarin and superwarfarin toxicity treated?

How is chronic warfarin and superwarfarin toxicity treated?

How is serious hemorrhage due to warfarin and superwarfarin toxicity treated?

Which specialist consultations are beneficial to patients with warfarin and superwarfarin toxicity?

What is included in long-term monitoring following the treatment for warfarin and superwarfarin toxicity?

Medications

What is the role of medications in the treatment of warfarin and superwarfarin toxicity?

Which medications in the drug class Blood Components are used in the treatment of Warfarin and Superwarfarin Toxicity?

Which medications in the drug class Antidotes, Other are used in the treatment of Warfarin and Superwarfarin Toxicity?