MDMA Toxicity Differential Diagnoses

Updated: Dec 16, 2016
  • Author: In-Hei Hahn, MD, FACEP, FACMT; Chief Editor: Jeter (Jay) Pritchard Taylor, III, MD  more...
  • Print

Diagnostic Considerations

Mephedrone (4-methylmethcathinone) is a novel psychoactive substance that produces effects similar to those of MDMA (3,4-methylenedioxymethamphetamine, ecstasy). Use of mephedrone has been associated with adverse effects and fatal intoxications. A study in 12 male volunteers found that mephedrone produced a significant increase in systolic and diastolic blood pressure, heart rate, and pupillary diameter, along with stimulant-like effects, euphoria, and well-being similar the effects of MDMA. However, the effects of mephedrone peaked earlier and were shorter in duration. [24]

Differential Diagnoses