Carpal Tunnel Syndrome in Emergency Medicine Medication

Updated: Nov 12, 2019
  • Author: Jonathan E Dangers, MD, MPH; Chief Editor: Trevor John Mills, MD, MPH  more...
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Medication Summary

The goal of therapy is to reduce inflammation and prevent complications.


Nonsteroidal anti-inflammatory agents

Class Summary

Most commonly are used for the relief of mild-to-moderate pain. Although the effects of NSAIDs in the treatment of pain tend to be patient specific, ibuprofen usually is the DOC for the initial therapy. Other options include flurbiprofen, ketoprofen, and naproxen.


May inhibit cyclo-oxygenase enzyme, which in turn inhibits prostaglandin biosynthesis. These effects may result in analgesic, antipyretic, and anti-inflammatory activities.

Ketoprofen (Active-Ketoprofen)

For relief of mild to moderate pain and inflammation. Small dosages initially are indicated in small and elderly patients and in those with renal or liver disease.

Doses over 75 mg do not increase therapeutic effects. Administer high doses with caution and closely observe patient for response.

Ibuprofen (I-prin, Advil, Motrin, Caldolor)

Usually the DOC for the treatment of mild-to-moderate pain if no contraindications exist.

Inhibits inflammatory reactions and pain, probably by decreasing the activity of cyclooxygenase enzyme, which results in the inhibition of prostaglandin synthesis.

Taking medication with at least 4 oz of water may minimize adverse effects.

Naproxen (Anaprox, Naprelan, Naprosyn, Aleve, Mediproxen)

Used for the relief of mild-to-moderate pain; inhibits inflammatory reactions and pain by decreasing activity of cyclooxygenase enzyme, which results in a decrease of prostaglandin synthesis. Inexpensive and effective.

Meloxicam (Mobic, Vivlodex)

Meloxicam decreases COX activity, and this, in turn, inhibits prostaglandin synthesis. These effects decrease the formation of inflammatory mediators.