Legg-Calve-Perthes Disease in Emergency Medicine Medication

Updated: Mar 03, 2018
  • Author: Jessica Hernandez, MD; Chief Editor: Trevor John Mills, MD, MPH  more...
  • Print

Medication Summary

Medical treatment does not stop or reverse the bony changes. Recent experimental studies have demonstrated some success with antiresorptive and anabolic agents for the treatment of Legg-Calvé-Perthes disease. However, further studies are needed to assess the safety and effectiveness in humans. [8]

In the emergency department setting, the focus should be on administering appropriate analgesic medication.


Nonsteroidal anti-inflammatory drugs (NSAIDs)

Class Summary

These drugs most commonly are used for the relief of mild to moderately severe pain. Although the effects of NSAIDs in the treatment of pain tend to be patient specific, ibuprofen is usually the drug of choice (DOC) for the initial therapy.

Ibuprofen (Advil, Motrin IB, Caldolor, I-Prin, Provil, NeoProfen, Genpril)

Ibuprofen is usually the DOC for the treatment of mild to moderately severe pain if there are no contraindications. It inhibits inflammatory reactions and pain, probably by decreasing the activity of enzyme cyclooxygenase, thus decreasing prostaglandin synthesis.

Ketoprofen (Active-Ketoprofen, Frotek, Ketophene Radiopaq)

Ketoprofen is used for the relief of mild to moderate pain and inflammation. Small doses are indicated initially in patients with small body size, elderly patients, and persons with renal or liver disease. Doses of over 75 mg do not increase therapeutic effects. Administer high doses with caution, and closely observe the patient for response.

Naproxen (Aleve, Naprosyn, Anaprox DS, Naprelan)

Naproxen is used for the relief of mild to moderate pain. It inhibits inflammatory reactions and pain by decreasing the activity of cyclo-oxygenase (COX), which is responsible for prostaglandin synthesis.



Class Summary

Pain control is essential to quality patient care. It ensures patient comfort, promotes pulmonary toilet, and relieves pain.

Acetaminophen (Tylenol, Acephen, Aspirin-Free Anacin Extra Strength, Mapap, Ofirmev)

Acetaminophen is the DOC for the treatment of pain in patients with documented hypersensitivity to aspirin and NSAIDs, as well as those with upper GI disease or those who are taking oral anticoagulants.