Lumbar (Intervertebral) Disc Disorder Management in the ED Medication

Updated: Aug 13, 2021
  • Author: Jere F Baldwin, MD; Chief Editor: Trevor John Mills, MD, MPH  more...
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Medication Summary

The goals of therapy are to reduce pain and inflammation. [26]


Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Class Summary

These agents are used most commonly for the relief of mild to moderately severe pain. Although effects of NSAIDs in the treatment of pain tend to be patient specific, ibuprofen usually is the DOC for initial therapy. Other options include flurbiprofen, ketoprofen, and naproxen.

Ibuprofen (Ibuprin, Advil, Motrin)

Usually DOC for treatment of mild to moderately severe pain if no contraindications.

Ketoprofen (Oruvail, Orudis, Actron)

Used for relief of mild to moderately severe pain and inflammation. Administer small dosages initially to patients with small body size, to elderly persons, and to those with renal or liver disease. Doses higher than 75 mg do not increase therapeutic effects. Administer high doses with caution, and closely observe patient for response.

Flurbiprofen (Ansaid)

May inhibit enzyme cyclooxygenase, which, in turn, inhibits prostaglandin biosynthesis. These effects may be mechanism of its analgesic, antipyretic, and anti-inflammatory activities.

Naproxen (Anaprox, Naprelan, Naprosyn)

Used for relief of mild to moderately severe pain. Inhibits inflammatory reactions and pain by decreasing activity of enzyme cyclooxygenase, causing decrease in prostaglandin synthesis.