CBRNE - T-2 Mycotoxins Medication

Updated: Mar 09, 2016
  • Author: Chan W Park, MD, FAAEM; Chief Editor: Zygmunt F Dembek, PhD, MPH, MS, LHD  more...
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Medication

Medication Summary

The use of activated charcoal is advocated to patients who have orally ingested the toxin. Some sources advocate the use of activated charcoal even after inhalational exposure with the rationale being that the toxin that is adherent to the oral mucosa may be bound. [27] While not clinically tested in human, theoretical use exists for administering colony-stimulating factors to patients presenting with bone marrow suppression.

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Antidotes, adsorbent

Class Summary

These agents are used to neutralize toxins. [25]

Activated charcoal (Liqui-Char, Super-Char, Insta-Char, Actidose)

Believed to adsorb ingested toxin, thereby preventing absorption and removing toxin from the GI tract, preventing further cellular damage.

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Granulocyte-stimulating factors

Class Summary

These agents are used to correct severe neutropenia.

Filgrastim (Neupogen)

Granulocyte colony-stimulating factor that activates and stimulates production, maturation, migration, and cytotoxicity of neutrophils. Although not demonstrated or indicated for use in T-2 mycotoxin exposure, may be theoretical use for granulocyte-stimulating factors for patients presenting with severe neutropenia; in this setting, conduct use with hematology consultation.

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