Malignant Nasopharyngeal Tumors Guidelines

Updated: Sep 24, 2018
  • Author: Ho-Sheng Lin, MD, FACS; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Guidelines

Guidelines Summary

Guidelines for the treatment of nasopharyngeal carcinoma (NPC), issued by the American College of Radiology (ACR) in 2015, include the following recommendations [71] :

  • Nasopharyngectomy, stereotactic radiation therapy (SRT), intensity-modulated radiation therapy (IMRT), or IMRT with concurrent chemotherapy are all acceptable treatments for locally recurrent NPC in the absence of distant disease
  • Patients who had poor tolerance to initial concurrent therapy for locally advanced NPC may omit or receive adjuvant chemotherapy, provided that it is administered in a timely manner and there is good recovery from the toxicity
  • Patients with locally advanced and bulky, invasive NPC are typically treated with concurrent chemoradiation, although sequential or adjuvant approaches are also acceptable
  • Patients with an isolated bone focus of metastatic disease may achieve lengthy progression-free survival when treated with definitive concurrent chemoradiation to the primary site, as well as definitive radiation or stereotactic body radiation therapy to the metastatic bone disease
  • A platinum doublet is the standard systemic regimen for recurrent or metastatic NPC