Metatarsal Stress Fracture Medication

Updated: Jan 16, 2019
  • Author: Valerie E Cothran, MD; Chief Editor: Craig C Young, MD  more...
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Medication Summary

Analgesics may be needed in the acute phase of the treatment for metatarsal stress fractures. The patient often encounters mild to moderate pain until a period of rest and/or immobilization has occurred.


Nonsteroidal anti-inflammatory drugs

Class Summary

These agents have analgesic, anti-inflammatory, and antipyretic activities. Their mechanism of action is not known, but these drugs may inhibit cyclooxygenase activity and prostaglandin synthesis. Other mechanisms may exist as well, such as inhibition of leukotriene synthesis, lysosomal enzyme release, lipoxygenase activity, neutrophil aggregation, and various cell membrane functions.

Ibuprofen (Advil, Motrin)

DOC for mild to moderate pain, if there are no contraindications. Ibuprofen inhibits inflammatory reactions and pain by inhibiting the activity of cyclooxygenase, which reduces prostaglandin synthesis.

Ketoprofen (Orudis, Actron, Oruvail)

For relief of mild to moderate pain and inflammation. Small dosages are indicated initially in patients with small body size, elderly patients, and those with renal or liver disease. Doses >75 mg do not increase therapeutic effects. Administer high doses with caution, and closely observe patient for response.

Naproxen (Aleve, Naprelan, Naprosyn, Anaprox)

For relief of mild to moderate pain; inhibits inflammatory reactions and pain by decreasing activity of cyclooxygenase, which is responsible for prostaglandin synthesis.

Flurbiprofen (Ansaid)

May inhibit cyclooxygenase enzyme, which in turn inhibits prostaglandin biosynthesis. These effects may result in analgesic, antipyretic, and anti-inflammatory activities.



Class Summary

Pain control is essential for quality patient care. Analgesics ensure patient comfort, promote pulmonary toilet, and have sedating properties, which are beneficial for patients who have sustained trauma or injuries.

Acetaminophen (Tylenol, Panadol, Paracetamol)

DOC for pain in patients with documented hypersensitivity to aspirin, NSAIDs, diagnosed with upper GI disease or on oral anticoagulants.

Hydrocodone bitartrate with acetaminophen (Vicodin, Lortab, Lorcet HD)

Drug combination indicated for moderate to severe pain.