Metatarsalgia Medication

Updated: Sep 22, 2023
  • Author: Britt A Durham, MD; Chief Editor: Sherwin SW Ho, MD  more...
  • Print

Medication Summary

Nonsteroidal anti-inflammatory drugs, such as ibuprofen, are useful for the symptomatic relief of the pain of metatarsalgia; however, these agents rarely provide a long-term solution.


Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Class Summary

NSAIDS are most commonly used for the relief of mild to moderate pain. Although the effects of these agents in the treatment of pain tend to be patient specific, ibuprofen is usually the drug of choice (DOC) for initial therapy. Options include ketoprofen and naproxen and many other NSAIDs.

Ibuprofen (Motrin, Ibuprin)

DOC for patients with mild to moderate pain. Inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.

Ketoprofen (Oruvail, Actron, Orudis)

For relief of mild to moderate pain and inflammation.

Small dosages are initially indicated in small and elderly patients and in those with renal or liver disease. Doses over 75 mg do not increase therapeutic effects. Administer high doses with caution, and closely observe patient for response.

Naproxen (Anaprox, Naprelan, Naprosyn, Anaprox)

For relief of mild to moderate pain; inhibits inflammatory reactions and pain by decreasing activity of cyclooxygenase, which results in a decrease of prostaglandin synthesis