Otitis Media With Effusion Questions & Answers

1. O'Connor SS, Coggins R, Gagnon L, Rosenfeld RM, Shin JJ, Walsh SA. Plain Language Summary: Otitis Media with Effusion. Otolaryngol Head Neck Surg. 2016 Feb. 154 (2):215-25. [QxMD MEDLINE Link]. [Full Text].

2. O'Connor SS, Coggins R, Gagnon L, Rosenfeld RM, Shin JJ, Walsh SA. Plain Language Summary: Otitis Media with Effusion. Otolaryngol Head Neck Surg. 2016 Feb. 154 (2):215-25. [QxMD MEDLINE Link]. [Full Text].

3. Minovi A, Dazert S. Diseases of the middle ear in childhood. GMS Curr Top Otorhinolaryngol Head Neck Surg. 2014. 13:Doc11. [QxMD MEDLINE Link]. [Full Text].

4. Pichichero ME, Poole MD. Assessing diagnostic accuracy and tympanocentesis skills in the management of otitis media. Arch Pediatr Adolesc Med. 2001 Oct. 155(10):1137-42. [QxMD MEDLINE Link].

5. Kaleida PH. Evidence assessment of the accuracy of methods of diagnosing middle ear effusion in children with otitis media with effusion. J Pediatr. 2004 Jul. 145(1):138. [QxMD MEDLINE Link].

6. [Guideline] Simon F, Haggard M, Rosenfeld RM, et al. International consensus (ICON) on management of otitis media with effusion in children. Eur Ann Otorhinolaryngol Head Neck Dis. 2018 Feb. 135 (1S):S33-9. [QxMD MEDLINE Link].

7. Bluestone CD, Beery QC, Andrus WS. Mechanics of the eustachian tube as it influences susceptibility to and persistence of middle ear effusions in children. Ann Otol Rhinol Laryngol. 1974 Mar-Apr. 83:Suppl 11:27-34. [QxMD MEDLINE Link].

8. Crapko M, Kerschner JE, Syring M, Johnston N. Role of extra-esophageal reflux in chronic otitis media with effusion. Laryngoscope. 2007 Jun 20. [QxMD MEDLINE Link].

9. O'Reilly RC, Soundar S, Tonb D, et al. The Role of Gastric Pepsin in the Inflammatory Cascade of Pediatric Otitis Media. JAMA Otolaryngol Head Neck Surg. 2015 Jan 29. [QxMD MEDLINE Link].

10. Yilmaz T, Koçan EG, Besler HT, Yilmaz G, Gürsel B. The role of oxidants and antioxidants in otitis media with effusion in children. Otolaryngol Head Neck Surg. 2004 Dec. 131(6):797-803. [QxMD MEDLINE Link].

11. Harman NL, Bruce IA, Callery P, Tierney S, Sharif MO, O Brien K, et al. MOMENT -- Management of Otitis Media with Effusion in Cleft Palate: protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey. Trials. 2013 Mar 12. 14(1):70. [QxMD MEDLINE Link].

12. Kubba H, Pearson JP, Birchall JP. The aetiology of otitis media with effusion: a review. Clin Otolaryngol. 2000 Jun. 25(3):181-94. [QxMD MEDLINE Link].

13. Siddartha, Bhat V, Bhandary SK, Shenoy V, Rashmi. Otitis media with effusion in relation to socio economic status: a community based study. Indian J Otolaryngol Head Neck Surg. 2012 Mar. 64(1):56-8. [QxMD MEDLINE Link]. [Full Text].

14. Erdivanli OC, Coskun ZO, Kazikdas KC, Demirci M. Prevalence of Otitis Media with Effusion among Primary School Children in Eastern Black Sea, in Turkey and the Effect of Smoking in the Development of Otitis Media with Effusion. Indian J Otolaryngol Head Neck Surg. 2012 Mar. 64(1):17-21. [QxMD MEDLINE Link]. [Full Text].

15. Mills R, Hathorn I. Aetiology and pathology of otitis media with effusion in adult life. J Laryngol Otol. 2016 May. 130 (5):418-24. [QxMD MEDLINE Link]. [Full Text].

16. Choi HG, Sim S, Kim SY, Lee HJ. A high-fat diet is associated with otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2015 Dec. 79 (12):2327-31. [QxMD MEDLINE Link].

17. Kaya S, Selimoglu E, Cureoglu S, Selimoglu MA. Relationship between chronic otitis media with effusion and overweight or obesity in children. J Laryngol Otol. 2017 Oct. 131 (10):866-70. [QxMD MEDLINE Link].

18. Walker RE, Bartley J, Flint D, Thompson JM, Mitchell EA. Determinants of chronic otitis media with effusion in preschool children: a case-control study. BMC Pediatr. 2017 Jan 6. 17 (1):4. [QxMD MEDLINE Link]. [Full Text].

19. Williamson I, Vennik J, Harnden A, et al. Effect of nasal balloon autoinflation in children with otitis media with effusion in primary care: an open randomized controlled trial. CMAJ. 2015 Sep 22. 187 (13):961-9. [QxMD MEDLINE Link]. [Full Text].

20. Kouwen HB, Dejonckere PH. Prevalence of OME is reduced in young children using chewing gum. Ear Hear. 2007 Aug. 28(4):451-5. [QxMD MEDLINE Link].

21. Williams RL, Chalmers TC, Stange KC, et al. Use of antibiotics in preventing recurrent acute otitis media and in treating otitis media with effusion. A meta-analytic attempt to resolve the brouhaha. JAMA. 1993 Sep 15. 270(11):1344-51. [QxMD MEDLINE Link].

22. Roditi RE, Liu CC, Bellmunt AM, Rosenfeld RM, Shin JJ. Oral Antibiotic Use for Otitis Media with Effusion: Ongoing Opportunities for Quality Improvement. Otolaryngol Head Neck Surg. 2016 May. 154 (5):797-803. [QxMD MEDLINE Link]. [Full Text].

23. Tracy JM, Demain JG, Hoffman KM, Goetz DW. Intranasal beclomethasone as an adjunct to treatment of chronic middle ear effusion. Ann Allergy Asthma Immunol. 1998 Feb. 80(2):198-206. [QxMD MEDLINE Link].

24. Simpson SA, Lewis R, van der Voort J, Butler CC. Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children. Cochrane Database Syst Rev. 2011 May 11. CD001935. [QxMD MEDLINE Link].

25. Simpson SA, Lewis R, van der Voort J, Butler CC. Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children. Cochrane Database Syst Rev. 2011 May 11. 5:CD001935. [QxMD MEDLINE Link].

26. Williamson I, Benge S, Barton S, et al. A double-blind randomised placebo-controlled trial of topical intranasal corticosteroids in 4- to 11-year-old children with persistent bilateral otitis media with effusion in primary care. Health Technol Assess. 2009 Aug. 13(37):1-144. [QxMD MEDLINE Link].

27. Cantekin EI, Mandel EM, Bluestone CD, et al. Lack of efficacy of a decongestant-antihistamine combination for otitis media with effusion ("secretory" otitis media) in children. Results of a double-blind, randomized trial. N Engl J Med. 1983 Feb 10. 308(6):297-301. [QxMD MEDLINE Link].

28. Griffin G, Flynn CA. Antihistamines and/or decongestants for otitis media with effusion (OME) in children. Cochrane Database Syst Rev. 2011 Sep 7. 9:CD003423. [QxMD MEDLINE Link].

29. [Guideline] Bann DV, Patel VA, Saadi RA, et al. Best Practice Recommendations for Pediatric Otolaryngology During the COVID-19 Pandemic. Otolaryngol Head Neck Surg. 2020. [Full Text].

30. Maw R, Bawden R. Spontaneous resolution of severe chronic glue ear in children and the effect of adenoidectomy, tonsillectomy, and insertion of ventilation tubes (grommets). BMJ. 1993 Mar 20. 306(6880):756-60. [QxMD MEDLINE Link].

31. Boston M, McCook J, Burke B, Derkay C. Incidence of and risk factors for additional tympanostomy tube insertion in children. Arch Otolaryngol Head Neck Surg. 2003 Mar. 129(3):293-6. [QxMD MEDLINE Link].

32. Burton MJ, Rosenfeld RM. Grommets (ventilation tubes) for hearing loss associated with otitis media with effusion in children. Otolaryngol Head Neck Surg. 2006 Oct. 135(4):507-10. [QxMD MEDLINE Link].

33. Barclay L. Postop Tympanostomy Tube Obstruction Common. Medscape Medical News. Jul 11 2014. [Full Text].

34. Conrad DE, Levi JR, Theroux ZA, et al. Risk Factors Associated With Postoperative Tympanostomy Tube Obstruction. JAMA Otolaryngol Head Neck Surg. 2014 Jul 10. [QxMD MEDLINE Link].

35. Mair EA, Moss JR, Dohar JE, Antonelli PJ, Bear M, LeBel C. Randomized Clinical Trial of a Sustained-Exposure Ciprofloxacin for Intratympanic Injection During Tympanostomy Tube Surgery. Ann Otol Rhinol Laryngol. 2015 Aug 20. [QxMD MEDLINE Link].

36. Brooks M. FDA OKs Otiprio for kids getting tympanostomy tube placement. Medscape Medical News. Dec 14, 2015. [Full Text].

37. [Guideline] Rosenfeld RM, Shin JJ, Schwartz SR, et al. Clinical practice guideline: otitis media with effusion (update). Otolaryngol Head Neck Surg. 2016 Feb. 154 (1 Suppl):S1-S41. [QxMD MEDLINE Link]. [Full Text].

38. University of Michigan Health System (UMHS). Otitis media. April 2013. Available at http://www.med.umich.edu/1info/FHP/practiceguides/om.html.

39. National Institute for Health and Care Excellence. Otitis media with effusion in under 12s: surgery. February 2008. Available at https://www.nice.org.uk/guidance/cg60/chapter/1-Guidance.

40. [Guideline] Rosenfeld RM, Tunkel DE, Schwartz SR, et al. Clinical Practice Guideline: Tympanostomy Tubes in Children (Update). Otolaryngol Head Neck Surg. 2022 Feb. 166 (1_suppl):S1-S55. [QxMD MEDLINE Link]. [Full Text].

41. [Guideline] Rosenfeld RM, Schwartz SR, Pynnonen MA, et al. Clinical practice guideline: tympanostomy tubes in children. Otolaryngol Head Neck Surg. 2013 Jul. 149 (1 Suppl):S1-35. [QxMD MEDLINE Link]. [Full Text].

42. Pichichero ME, Reiner SA, Brook I, et al. Controversies in the medical management of persistent and recurrent acute otitis media. Recommendations of a clinical advisory committee. Ann Otol Rhinol Laryngol Suppl. 2000 Aug. 183:1-12. [QxMD MEDLINE Link].

43. [Guideline] Frellick M. Otitis Media: New Guideline Includes Screening At-Risk Kids. Medscape Medical News. 2016 Feb 4. [Full Text].

Thomas S Higgins, Jr, MD, MSPH Rhinologist and Associate in Otolaryngology-Head and Neck Surgery, Kentuckiana Ear, Nose and Throat, PSC

Disclosure: Serve(d) as a speaker or a member of a speakers bureau for: Acclarent; IntersectENT.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Arlen D Meyers, MD, MBA Professor of Otolaryngology, Dentistry, and Engineering, University of Colorado School of Medicine

Arlen D Meyers, MD, MBA is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American Head and Neck Society

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Cerescan; Ryte; Neosoma; MI10<br/>Received income in an amount equal to or greater than $250 from: Neosoma; Cyberionix (CYBX)<br/>Received ownership interest from Cerescan for consulting for: Neosoma, MI10.

Gregory C Allen, MD Assistant Professor, Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine

Disclosure: Nothing to disclose.

Richard D Thrasher III, MD Private Practice, McKinney, Texas

Richard D Thrasher III, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American Medical Association, and American Rhinologic Society

Disclosure: Nothing to disclose.

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