Fungal Sinusitis Questions & Answers

1. Ponikau JU, Sherris DA, Kern EB, et al. The diagnosis and incidence of allergic fungal sinusitis. Mayo Clin Proc. 1999 Sep. 74 (9):877-84. [QxMD MEDLINE Link].

2. Shin SH, Ponikau JU, Sherris DA, et al. Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi. J Allergy Clin Immunol. 2004 Dec. 114 (6):1369-75. [QxMD MEDLINE Link].

3. Sasama J, Sherris DA, Shin SH, Kephart GM, Kern EB, Ponikau JU. New paradigm for the roles of fungi and eosinophils in chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg. 2005 Feb. 13 (1):2-8. [QxMD MEDLINE Link].

4. Gosepath J, Mann WJ. Role of fungus in eosinophilic sinusitis. Curr Opin Otolaryngol Head Neck Surg. 2005 Feb. 13 (1):9-13. [QxMD MEDLINE Link].

5. Hussain S, Salahuddin N, Ahmad I, Salahuddin I, Jooma R. Rhinocerebral invasive mycosis: occurrence in immunocompetent individuals. Eur J Radiol. 1995 Jul. 20 (2):151-5. [QxMD MEDLINE Link].

6. Scharf JL, Soliman AM. Chronic rhizopus invasive fungal rhinosinusitis in an immunocompetent host. Laryngoscope. 2004 Sep. 114 (9):1533-5. [QxMD MEDLINE Link].

7. Siddiqui AA, Shah AA, Bashir SH. Craniocerebral aspergillosis of sinonasal origin in immunocompetent patients: clinical spectrum and outcome in 25 cases. Neurosurgery. 2004 Sep. 55 (3):602-11; discussion 611-3. [QxMD MEDLINE Link].

8. Akhondi H, Woldemariam B, Rajasurya V. Fungal Sinusitis. StatPearls. 2022 Jan. [QxMD MEDLINE Link]. [Full Text].

9. Raz E, Win W, Hagiwara M, Lui YW, Cohen B, Fatterpekar GM. Fungal Sinusitis. Neuroimaging Clin N Am. 2015 Nov. 25 (4):569-76. [QxMD MEDLINE Link].

10. Manning SC, Merkel M, Kriesel K, Vuitch F, Marple B. Computed tomography and magnetic resonance diagnosis of allergic fungal sinusitis. Laryngoscope. 1997 Feb. 107 (2):170-6. [QxMD MEDLINE Link].

11. Lu-Myers Y, Deal AM, Miller JD, et al. Comparison of Socioeconomic and Demographic Factors in Patients with Chronic Rhinosinusitis and Allergic Fungal Rhinosinusitis. Otolaryngol Head Neck Surg. 2015 Jul. 153 (1):137-43. [QxMD MEDLINE Link].

12. Pant H, Schembri MA, Wormald PJ, Macardle PJ. IgE-mediated fungal allergy in allergic fungal sinusitis. Laryngoscope. 2009 Jun. 119 (6):1046-52. [QxMD MEDLINE Link].

13. Gupta R, Gupta AK, Patro SK, et al. Allergic fungal rhino sinusitis with granulomas: A new entity?. Med Mycol. 2015 Aug. 53 (6):569-75. [QxMD MEDLINE Link].

14. Paknezhad H, Borchard NA, Charville GW, et al. Evidence for a 'preinvasive' variant of fungal sinusitis: Tissue invasion without angioinvasion. World J Otorhinolaryngol Head Neck Surg. 2017 Mar. 3 (1):37-43. [QxMD MEDLINE Link]. [Full Text].

15. Turner JH, Soudry E, Nayak JV, Hwang PH. Survival outcomes in acute invasive fungal sinusitis: a systematic review and quantitative synthesis of published evidence. Laryngoscope. 2013 May. 123 (5):1112-8. [QxMD MEDLINE Link].

16. Lieberman SM, Jacobs JB, Lebowitz RA, Fitzgerald MB, Crawford J, Feigenbaum BA. Measurement of mycotoxins in patients with chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2011 Aug. 145 (2):327-9. [QxMD MEDLINE Link].

17. Payne SJ, Mitzner R, Kunchala S, Roland L, McGinn JD. Acute Invasive Fungal Rhinosinusitis: A 15-Year Experience with 41 Patients. Otolaryngol Head Neck Surg. 2016 Apr. 154 (4):759-64. [QxMD MEDLINE Link].

18. Melancon CC, Lindsey J, Russell GB, Clinger JD. The role of galactomannan Aspergillus antigen in diagnosing acute invasive fungal sinusitis. Int Forum Allergy Rhinol. 2019 Jan. 9 (1):60-6. [QxMD MEDLINE Link].

19. Middlebrooks EH, Frost CJ, De Jesus RO, Massini TC, Schmalfuss IM, Mancuso AA. Acute Invasive Fungal Rhinosinusitis: A Comprehensive Update of CT Findings and Design of an Effective Diagnostic Imaging Model. AJNR Am J Neuroradiol. 2015 Aug. 36 (8):1529-35. [QxMD MEDLINE Link].

20. Cha H, Song Y, Bae YJ, et al. Clinical Characteristics Other Than Intralesional Hyperdensity May Increase the Preoperative Diagnostic Accuracy of Maxillary Sinus Fungal Ball. Clin Exp Otorhinolaryngol. 2020 May. 13 (2):157-63. [QxMD MEDLINE Link]. [Full Text].

21. Kim SC, Ryoo I, Shin JM, Suh S, Jung HN, Shin SU. MR Findings of Fungus Ball: Significance of High Signal Intensity on T1-Weighted Images. J Korean Med Sci. 2020 Jan 20. 35 (3):e22. [QxMD MEDLINE Link]. [Full Text].

22. Melancon CC, Clinger JD. The Use of Frozen Section in the Early Diagnosis of Acute Invasive Fungal Sinusitis. Otolaryngol Head Neck Surg. 2017 Aug. 157 (2):314-9. [QxMD MEDLINE Link].

23. Mabry RL, Mabry CS. Allergic fungal sinusitis: the role of immunotherapy. Otolaryngol Clin North Am. 2000 Apr. 33 (2):433-40. [QxMD MEDLINE Link].

24. Bassichis BA, Marple BF, Mabry RL, Newcomer MT, Schwade ND. Use of immunotherapy in previously treated patients with allergic fungal sinusitis. Otolaryngol Head Neck Surg. 2001 Nov. 125 (5):487-90. [QxMD MEDLINE Link].

25. Mehta R, Panda NK, Mohindra S, Chakrabarti A, Singh P. Comparison of efficacy of amphotericin B and itraconazole in chronic invasive fungal sinusitis. Indian J Otolaryngol Head Neck Surg. 2013 Aug. 65 (Suppl 2):288-94. [QxMD MEDLINE Link]. [Full Text].

26. Masterson L, Egro FM, Bewick J, et al. Quality-of-life outcomes after sinus surgery in allergic fungal rhinosinusitis versus nonfungal chronic rhinosinusitis. Am J Rhinol Allergy. 2016 Mar-Apr. 30 (2):e30-5. [QxMD MEDLINE Link].

27. Anselmo-Lima WT, Lopes RP, Valera FC, Demarco RC. Invasive fungal rhinosinusitis in immunocompromised patients. Rhinology. 2004 Sep. 42 (3):141-4. [QxMD MEDLINE Link].

28. Loftus CA, Soler ZM, Koochakzadeh S, et al. Revision surgery rates in chronic rhinosinusitis with nasal polyps: meta-analysis of risk factors. Int Forum Allergy Rhinol. 2020 Feb. 10 (2):199-207. [QxMD MEDLINE Link].

29. Raut A, Huy NT. Rising incidence of mucormycosis in patients with COVID-19: another challenge for India amidst the second wave?. Lancet Respir Med. 2021 Aug. 9 (8):e77. [QxMD MEDLINE Link]. [Full Text].

30. Banerjee M, Pal R, Bhadada SK. Intercepting the deadly trinity of mucormycosis, diabetes and COVID-19 in India. Postgrad Med J. 2021 Jun 8. [QxMD MEDLINE Link]. [Full Text].

31. Winny A. COVID-19 and Fungi: A Nightmare in the Making. Johns Hopkins Bloomberg School of Public Health. Available at https://publichealth.jhu.edu/2021/covid-19-and-fungi-a-nightmare-in-the-making. July 1, 2021; Accessed: October 20, 2022.

32. Green KK, Barham HP, Allen GC, Chan KH. Prognostic Factors in the Outcome of Invasive Fungal Sinusitis in a Pediatric Population. Pediatr Infect Dis J. 2016 Apr. 35 (4):384-6. [QxMD MEDLINE Link].

33. Smith A, Thimmappa V, Shepherd B, Ray M, Sheyn A, Thompson J. Invasive fungal sinusitis in the pediatric population: Systematic review with quantitative synthesis of the literature. Int J Pediatr Otorhinolaryngol. 2016 Nov. 90:231-5. [QxMD MEDLINE Link].

34. Wise SK, Venkatraman G, Wise JC, DelGaudio JM. Ethnic and gender differences in bone erosion in allergic fungal sinusitis. Am J Rhinol. 2004 Nov-Dec. 18(6):397-404. [QxMD MEDLINE Link].

Hassan H Ramadan, MD, MSc, FACS, FARS Professor and Chairman, Director of Rhinology and Allergy Center, Department of Otolaryngology-Head and Neck Surgery, Professor, Department of Pediatrics, West Virginia University School of Medicine

Hassan H Ramadan, MD, MSc, FACS, FARS is a member of the following medical societies: American Academy of Otolaryngic Allergy, American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Rhinologic Society

Disclosure: Nothing to disclose.

Chadi A Makary, MD Clinical Instructor, Fellow in Rhinology and Endoscopic Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, Medical College of Georgia at Augusta University

Chadi A Makary, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Otolaryngology-Head and Neck Surgery, American Rhinologic Society, International Otopathology Society (Schuknecht Society), Triological Society

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Stephen G Batuello, MD Consulting Staff, Colorado ENT Specialists

Stephen G Batuello, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American Association for Physician Leadership, American Medical Association, Colorado Medical Society

Disclosure: Nothing to disclose.

Arlen D Meyers, MD, MBA Professor of Otolaryngology, Dentistry, and Engineering, University of Colorado School of Medicine

Arlen D Meyers, MD, MBA is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American Head and Neck Society

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Cerescan; Ryte; Neosoma; MI10<br/>Received income in an amount equal to or greater than $250 from: Neosoma; Cyberionix (CYBX)<br/>Received ownership interest from Cerescan for consulting for: Neosoma, MI10.

Lanny Garth Close, MD Chair, Professor, Department of Otolaryngology-Head and Neck Surgery, Columbia University College of Physicians and Surgeons

Lanny Garth Close, MD is a member of the following medical societies: Alpha Omega Alpha, American Head and Neck Society, American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American College of Physicians, American Laryngological Association, New York Academy of Medicine

Disclosure: Nothing to disclose.

• Print this section
• Print the entire contents of
• Print the entire contents of article