Aphthous Ulcers Questions & Answers

1. Wiriyakijja P, Porter S, Fedele S, et al. Validation of the HADS and PSS-10 and a cross-sectional study of psychological status in patients with recurrent aphthous stomatitis. J Oral Pathol Med. 2020 Mar. 49 (3):260-70. [QxMD MEDLINE Link].

2. Akintoye SO, Greenberg MS. Recurrent aphthous stomatitis. Dent Clin North Am. 2014 Apr. 58 (2):281-97. [QxMD MEDLINE Link]. [Full Text].

3. Scully C. Myths or legends and RAS. Oral Dis. 2012 Jul. 18(5):521; author reply 520. [QxMD MEDLINE Link].

4. Preeti L, Magesh K, Rajkumar K, Karthik R. Recurrent aphthous stomatitis. J Oral Maxillofac Pathol. 2011 Sep. 15(3):252-6. [QxMD MEDLINE Link]. [Full Text].

5. Shotts RH, Scully C, Avery CM, Porter SR. Nicorandil-induced severe oral ulceration: a newly recognized drug reaction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Jun. 87(6):706-7. [QxMD MEDLINE Link].

6. Gulseren D, Hapa A, Ersoy-Evans S, Elcin G, Karaduman A. Is there a role of food additives in recurrent aphthous stomatitis? A prospective study with patch testing. Int J Dermatol. 2016 Dec 30. [QxMD MEDLINE Link].

7. Zhang Z, Li S, Fang H. Enzymatic antioxidants status in patients with recurrent aphthous stomatitis. J Oral Pathol Med. 2017 Jan 5. [QxMD MEDLINE Link].

8. Wiriyakijja P, Porter S, Fedele S, et al. Validation of the HADS and PSS-10 and a cross-sectional study of psychological status in patients with recurrent aphthous stomatitis. J Oral Pathol Med. 2020 Mar. 49 (3):260-70. [QxMD MEDLINE Link].

9. Chen L, Ke Z, Zhou Z, Jiang X, Zhao Y, Zhang J. Associations of IL-1, 6, and 10 Gene Polymorphisms with Susceptibility to Recurrent Aphthous Stomatitis: Insights from a Meta-Analysis. Genet Test Mol Biomarkers. 2018 Apr. 22 (4):237-45. [QxMD MEDLINE Link].

10. Wu J, Wang W. Association between interleukin family gene polymorphisms and recurrent aphthous stomatitis risk. Genes Immun. 2018 Mar 18. [QxMD MEDLINE Link].

11. Tecco S, Sciara S, Pantaleo G, et al. The association between minor recurrent aphthous stomatitis (RAS), children's poor oral condition, and underlying negative psychosocial habits and attitudes towards oral hygiene. BMC Pediatr. 2018 Apr 13. 18 (1):136. [QxMD MEDLINE Link]. [Full Text].

12. Gülseren D, Karaduman A, Kutsal D, Nohutcu RM. The relationship between recurrent aphthous stomatitis, and periodontal disease and Helicobacter Pylori infection. Clin Oral Investig. 2016 Jan 6. [QxMD MEDLINE Link].

13. Hijazi K, Lowe T, Meharg C, et al. Mucosal Microbiome in Patients with Recurrent Aphthous Stomatitis. J Dent Res. 2014 Dec 24. [QxMD MEDLINE Link].

14. Kim YJ, Choi YS, Baek KJ, Yoon SH, Park HK, Choi Y. Mucosal and salivary microbiota associated with recurrent aphthous stomatitis. BMC Microbiol. 2016 Apr 1. 16 Suppl 1:57. [QxMD MEDLINE Link]. [Full Text].

15. Stehlikova Z, Tlaskal V, Galanova N, et al. Oral Microbiota Composition and Antimicrobial Antibody Response in Patients with Recurrent Aphthous Stomatitis. Microorganisms. 2019 Dec 1. 7 (12):[QxMD MEDLINE Link]. [Full Text].

16. Baccaglini L, Lalla RV, Bruce AJ, Sartori-Valinotti JC, Latortue MC, Carrozzo M, et al. Urban legends: recurrent aphthous stomatitis. Oral Dis. 2011 Nov. 17(8):755-70. [QxMD MEDLINE Link]. [Full Text].

17. Brocklehurst P, Tickle M, Glenny AM, Lewis MA, Pemberton MN, Taylor J, et al. Systemic interventions for recurrent aphthous stomatitis (mouth ulcers). Cochrane Database Syst Rev. 2012 Sep 12. 9:CD005411. [QxMD MEDLINE Link].

18. Volkov I, Rudoy I, Freud T, et al. Effectiveness of vitamin B12 in treating recurrent aphthous stomatitis: a randomized, double-blind, placebo-controlled trial. J Am Board Fam Med. 2009 Jan-Feb. 22 (1):9-16. [QxMD MEDLINE Link]. [Full Text].

19. Albrektson M, Hedström L, Bergh H. Recurrent aphthous stomatitis and pain management with low-level laser therapy: a randomized controlled trial. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 May. 117(5):590-4. [QxMD MEDLINE Link].

20. Khaleel Ahmed M, Jafer M, Nayeem M, et al. Low-Level Laser Therapy and Topical Medications for Treating Aphthous Ulcers: A Systematic Review. J Multidiscip Healthc. 2020. 13:1595-1605. [QxMD MEDLINE Link]. [Full Text].

21. Rocca JP, Zhao M, Fornaini C, Tan L, Zhao Z, Merigo E. Effect of laser irradiation on aphthae pain management: A four different wavelengths comparison. J Photochem Photobiol B. 2018 Dec. 189:1-4. [QxMD MEDLINE Link].

22. Liu C, Zhou Z, Liu G, Wang Q, Chen J, Wang L, et al. Efficacy and safety of dexamethasone ointment on recurrent aphthous ulceration. Am J Med. 2012 Mar. 125(3):292-301. [QxMD MEDLINE Link].

Jaisri R Thoppay, DDS, MBA, MS President, Center for Integrative Oral Health, Inc

Jaisri R Thoppay, DDS, MBA, MS is a member of the following medical societies: American Academy of Oral Medicine, American Academy of Orofacial Pain, American Association for Dental Research, American Dental Association, American Dental Education Association, International Association for Dental Research, Richmond Dental Society, Virginia Dental Association

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Robert M Kellman, MD Professor and Chair, Department of Otolaryngology and Communication Sciences, State University of New York Upstate Medical University

Robert M Kellman, MD is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Head and Neck Society, American Rhinologic Society, Triological Society, American Neurotology Society, American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Medical Association, Medical Society of the State of New York

Disclosure: Nothing to disclose.

Arlen D Meyers, MD, MBA Emeritus Professor of Otolaryngology, Dentistry, and Engineering, University of Colorado School of Medicine

Arlen D Meyers, MD, MBA is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American Head and Neck Society

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Cerescan; Neosoma; MI10;<br/>Received income in an amount equal to or greater than $250 from: Neosoma; Cyberionix (CYBX)<br/>Received ownership interest from Cerescan for consulting for: Neosoma, MI10 advisor.

Crispian Scully, MD, MRCS, PhD, MDS, CBE, FDSRCS(Eng), FDSRCPS, FFDRCSI, FDSRCSE, FRCPath, FMedSci, FHEA, FUCL, FSB, DSc, DChD, DMed(HC), Dr(HC) Emeritus Professor, University College London; Visiting Professor, Universities of Athens, BPP, Edinburgh, Granada, Helsinki and Plymouth

Crispian Scully, MD, MRCS, PhD, MDS, CBE, FDSRCS(Eng), FDSRCPS, FFDRCSI, FDSRCSE, FRCPath, FMedSci, FHEA, FUCL, FSB, DSc, DChD, DMed(HC), Dr(HC) is a member of the following medical societies: Academy of Medical Sciences, British Society for Oral Medicine, European Association for Oral Medicine, International Academy of Oral Oncology, International Association for Dental Research, International Association for Oral and Maxillofacial Pathology

Disclosure: Nothing to disclose.

Hassan H Ramadan, MD, MSc, FACS, FARS Professor and Chairman, Director of Rhinology and Allergy Center, Department of Otolaryngology-Head and Neck Surgery, Professor, Department of Pediatrics, West Virginia University School of Medicine

Hassan H Ramadan, MD, MSc, FACS, FARS is a member of the following medical societies: American Academy of Otolaryngic Allergy, American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Rhinologic Society

Disclosure: Nothing to disclose.

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