Mandibular Alveolar Fractures Medication

Updated: Sep 26, 2018
  • Author: William D Clark, MD, DDS; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and prevent complications.

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Analgesics

Class Summary

Pain control is essential to quality patient care. Analgesics ensure patient comfort, promote pulmonary toilet, and have sedating properties beneficial to patients who experience pain.

Acetaminophen (Acephen, Cetafen, Little Fevers, Mapap, Tylenol, Q-Pap, Valorin)

This agent may inhibit prostaglandin synthesis in the central nervous system (CNS) and operate peripherally to block the generation of pain impulses.

Codeine/acetaminophen (Tylenol with Codeine #3, Tylenol with Codeine #4, Capital/Codeine)

This combination is used for the relief of moderate to severe pain. By binding to opioid receptors in the CNS, codeine inhibits ascending pain pathways, altering the perception and response to pain. Acetaminophen may operate peripherally to block the generation of pain impulses.

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Antibiotics

Class Summary

Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting.

Penicillin G aqueous (Pfizerpen-G)

Penicillin G interferes with the synthesis of cell wall mucopeptide during active multiplication, resulting in bactericidal activity against susceptible microorganisms.

Clindamycin (Cleocin)

This agent is a semisynthetic antibiotic produced by 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compound, lincomycin. Clindamycin is a bacterial growth inhibitor; it may block the dissociation of peptidyl transfer ribonucleic acid (tRNA) from ribosomes, halting the synthesis of RNA-dependent protein. The drug does not penetrate the CNS, despite being widely distributed in the body. Protein bound, clindamycin is excreted by the liver and kidneys.

Amoxicillin (Moxatag)

Amoxicillin is often used in place of penicillin, but it has not been demonstrated to be more effective. The drug binds to penicillin-binding proteins, inhibiting bacterial cell wall growth.

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