Agammaglobulinemia Questions & Answers

Updated: Jul 08, 2019
  • Author: Donald A Person, MD, FAAP, FACR; Chief Editor: Harumi Jyonouchi, MD  more...
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Questions & Answers

Overview

What is agammaglobulinemia (hypogammaglobulinemia)?

What is the pathophysiology of agammaglobulinemia (hypogammaglobulinemia)?

What is the prevalence of agammaglobulinemia (hypogammaglobulinemia) in the US?

What is the global prevalence of agammaglobulinemia (hypogammaglobulinemia)?

What is the mortality and morbidity associated with agammaglobulinemia (hypogammaglobulinemia)?

What are the sexual predilections of agammaglobulinemia (hypogammaglobulinemia)?

At what age does agammaglobulinemia (hypogammaglobulinemia) typically first present?

Presentation

Which clinical history findings are characteristic of agammaglobulinemia (hypogammaglobulinemia)?

Which physical findings are characteristic of agammaglobulinemia (hypogammaglobulinemia)?

What causes agammaglobulinemia (hypogammaglobulinemia)?

DDX

What are the differential diagnoses for Agammaglobulinemia?

Workup

What is the role of lab testing in the workup of agammaglobulinemia (hypogammaglobulinemia)?

What is the role of imaging studies in the workup of agammaglobulinemia (hypogammaglobulinemia)?

What is the role of pulmonary function testing (PFT) in the workup of agammaglobulinemia (hypogammaglobulinemia)?

What is the role of auditory testing in the workup of agammaglobulinemia (hypogammaglobulinemia)?

What is the role of bronchoscopy in the workup of agammaglobulinemia (hypogammaglobulinemia)?

What is the role of endoscopy and colonoscopy in the workup of agammaglobulinemia (hypogammaglobulinemia)?

Which histologic findings are characteristics of agammaglobulinemia (hypogammaglobulinemia)?

Treatment

How is agammaglobulinemia (hypogammaglobulinemia) treated?

What is the role of surgery in the treatment of agammaglobulinemia (hypogammaglobulinemia)?

Which specialist consultations are beneficial to patients with agammaglobulinemia (hypogammaglobulinemia)?

Medications

What is the role of IV immunoglobulin therapy in the treatment of agammaglobulinemia (hypogammaglobulinemia)?

Which medications in the drug class Immune Globulin, Subcutaneous are used in the treatment of Agammaglobulinemia?

Which medications in the drug class Antibodies are used in the treatment of Agammaglobulinemia?

Follow-up

What is included in the long-term monitoring of agammaglobulinemia (hypogammaglobulinemia)?

When is inpatient care indicated for the treatment of agammaglobulinemia (hypogammaglobulinemia)?

Which medications are used in the treatment of agammaglobulinemia (hypogammaglobulinemia)?

What are the possible complications of agammaglobulinemia (hypogammaglobulinemia)?

What is the prognosis of agammaglobulinemia (hypogammaglobulinemia)?

Where can patient support and education resources about agammaglobulinemia (hypogammaglobulinemia) be found?