Pediatric Common Variable Immunodeficiency Questions & Answers

Updated: Oct 16, 2018
  • Author: C Lucy Park, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Questions & Answers

Overview

What is common variable immunodeficiency (CVID)?

What are the signs and symptoms of common variable immunodeficiency (CVID)?

What is the basis for a diagnosis of common variable immunodeficiency (CVID)?

How is common variable immunodeficiency (CVID) treated?

What is the most common immunologic defect in common variable immunodeficiency (CVID)?

Which B-cell defects are found in common variable immunodeficiency (CVID)?

Which T-cell defects are found in common variable immunodeficiency (CVID)?

What is the role of peripheral blood dendritic cells (DCs) in common variable immunodeficiency (CVID)?

What is the role of complement split products in common variable immunodeficiency (CVID)?

Which defects are found in common variable immunodeficiency (CVID)?

What is the morbidity and mortality associated with common variable immunodeficiency (CVID)?

What is the US prevalence of common variable immunodeficiency (CVID)?

What is the global prevalence of common variable immunodeficiency (CVID)?

What are the racial predilections of common variable immunodeficiency (CVID)?

At what age is common variable immunodeficiency (CVID) typically diagnosed?

Presentation

Which clinical history findings are characteristic of common variable immunodeficiency (CVID)?

Which infections are associated with common variable immunodeficiency (CVID)?

Which autoimmune conditions are associated with common variable immunodeficiency (CVID)?

Which granulomatous and lymphoid diseases are associated with common variable immunodeficiency (CVID)?

What is the increased risk for malignancy in common variable immunodeficiency (CVID)?

Which physical findings are characteristic of common variable immunodeficiency (CVID)?

What causes common variable immunodeficiency (CVID)?

DDX

What are the differential diagnoses for Pediatric Common Variable Immunodeficiency?

Workup

How is common variable immunodeficiency (CVID) diagnosed?

What is the role of imaging studies in the workup of common variable immunodeficiency (CVID)?

What is the role of pulmonary function tests (PFTs) in the diagnosis of common variable immunodeficiency (CVID)?

What is the role of bronchoscopy in the workup of common variable immunodeficiency (CVID)?

What is the role of lung biopsy in the workup of common variable immunodeficiency (CVID)?

Which histologic findings of lymph node biopsy findings are characteristic of common variable immunodeficiency (CVID)?

Which histologic findings of intestinal biopsy are characteristic of common variable immunodeficiency (CVID)?

How are malignancies complicating common variable immunodeficiency staged?

Treatment

How are infections prevented in common variable immunodeficiency (CVID)?

What is the role of IVIG in the treatment of common variable immunodeficiency (CVID)?

How is IVIG therapy administered for the treatment of common variable immunodeficiency (CVID)?

What is the nonanaphylactic adverse effects of IVIG therapy for the treatment of common variable immunodeficiency (CVID)?

What causes anaphylactic reactions to IVIG therapy for the treatment of common variable immunodeficiency (CVID)?

What is the risk for transmission of infectious agents through IVIG to treat common variable immunodeficiency (CVID)?

What is the role of SCIG in the treatment of common variable immunodeficiency (CVID)?

What is the role of antimicrobials in the treatment of common variable immunodeficiency (CVID)?

How does IVIG therapy affect arthritis and GI diseases associated with common variable immunodeficiency (CVID)?

What is the role of corticosteroids in the treatment of common variable immunodeficiency (CVID)?

What is the role of cyclosporin A in the treatment of common variable immunodeficiency (CVID)?

What is the role of anti-CD20 monoclonal antibodies in the treatment of common variable immunodeficiency (CVID)?

What is the role of IL-2 conjugated with polyethylene glycol (PEG) in the treatment of common variable immunodeficiency (CVID)?

How are chronic lung diseases treated in patients with common variable immunodeficiency (CVID)?

What is the role of surgery in the treatment of common variable immunodeficiency (CVID)?

Which specialist consultations are beneficial to patients with common variable immunodeficiency (CVID)?

Which dietary modifications are used in the treatment of common variable immunodeficiency (CVID)?

Which activity modifications are used in the treatment of common variable immunodeficiency (CVID)?

Medications

What is the role of medications in the treatment of common variable immunodeficiency (CVID)?

Follow-up

When is inpatient care indicated for the treatment of common variable immunodeficiency (CVID)?

What is the prognosis of common variable immunodeficiency (CVID)?

What is included in patient education about common variable immunodeficiency (CVID)?